28 results
Aims of the Study: Our main aim is to characterize cortical brain plasticity in individuals with impaired fasting glucose (IFG) and patients with type II diabetes mellitus (DM2) as compared with age-, gender-, and IQ-matched healthy controls(HC).•…
To assess safety, tolerability and pharmacokinetics of a single subcutaneous administration of HPV-NIRD1.
The primary objective is to correlate ex vivo 111In-exendin tracer accumulation in the pancreas of patients undergoing pancreatectomy for pancreatic cancer or chronic pancreatitis to establish the relation between tracer uptake and beta cell mass in…
The aim of this study is to compare the integrity of the corticospinal tract and cortical reorganization of shoulder girdle muscle representations in chronic stroke patients with and without GHS as well as healthy controls.
Primary Objective: The primary objective is to determine whether the administration of Gelofusine will reduce the kidney uptake of 111In-labeled exendin in humans by enhancing the excretion of 111In-labeled exendin. These highly relevant data can…
To investigate how quickly and to what extent diclofenac is absorbed and eliminated from the body (this is called pharmacokinetics) when it is administrated by using a HP 5000 transdermal patch. Furthermore, the pharmacokinetics of HP-5000…
The primary objective is to investigate the influence of vigilance state on MEP amplitude in healthy adults. Secondary objectives are to develop a paradigm to stabilize vigilance state resulting in lower MEP amplitude variability in healthy adults…
PRIMARY OBJECTIVES Part I - To evaluate the efficacy (as measured by PFS) of GDC-0941 340 mg +carboplatin * paclitaxel (Arm A) versus carboplatin * paclitaxel (Arm B) in all patients with squamous NSCLC -To evaluate the efficacy (as measured by PFS…
Can this effect be utilised clinically, especially in patients with major depressive disorder?
The primary objective is to evaluate the effect of a once-a-weekprophylaxis regimen with BAY 79-4980 on the protection from all bleeds compared to a three times-per-week prophylaxis regimen with rFVIII-FSWFI.
To assess the safety and tolerability of escalating single IV doses of NI-0801.To determine the pharmacokinetics and pharmacodynamics parameters of escalating single IV doses of NI-0801.
Probleemstelling: Er is geen duidelijkheid of rTMS, toegepast binnen het reguliere revalidatieprogramma na een beroerte, leidt tot een extra verbetering in motorische herstel volgens de klinimetrie zoals gehanteerd binnen de in Nederland gebruikte…
The goal of the current study is to investigate the functional relevance of higher order cortical areas for cognitive task execution involving inhibitory and emotional processes by means of TMS.
We plan to (1) prove that microTMS can influence brain connectivity in healthy volunteers, and (2) optimize the stimulation parameters. As soon as a considerable effect is obtained, the new project will follow up for patients.
The objective of this study is to assess the efficacy and safety of adalimumab in combination with a topical treatment for the treatment of patients with moderate to severe chronic plaque psoriasis.
The primary objectives of this study is:* To determine the safety and tolerability of rhHNS via ascending doses administered via a surgically implanted intrathecal drug device (IDDD) once monthly for 6 months, in patientswith MPS IIIA.The secondary…
The co-primary objectives of this study are: * To evaluate the efficacy of as measured by investigator-assessed PFS according to Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1). * To evaluate the efficacy of atezolizumab as…
The purpose of this study is to investigate how quickly and to what extent different doses of EUapproved Tysabri® are absorbed and eliminated from the body (this is called pharmacokinetics) and how the body responds to different doses of Tysabri (…
The main objective of this study is to investigate whether rTMS add-on treatment will improve clinical outcomes in alcohol dependence. The secondary objective will be to answer the question through which mechanism rTMS will improve treatment…