33 results
Primary objective:To determine the MTD/recommended dose for further study of oral LOXO-292 in patients with advanced solid tumors, including RET-fusion NSCLC, MTC, and other tumors with increased RET activity.Secondary objectives:* To determine the…
To determine 1) interindividual variation in pharmacokinetic parameters in patients with non-detectable trough levels of IFX and 2) whether the area under the curve (AUC) of the IFX serum concentration during one infusion cycle predicts relapse…
The main objective of this study is to validate the accuracy of the device to monitor the physical activity of a subject by comparing the measured values to the golden standard (video recording).
The main objectives of this study are to determine the accuracy of the device (1) to determine functional oxygen saturation (SpO2) compared to a reference device, and (2) to determine respiratory rate compared to visual observations. As a secondary…
With this study we hope to improve the closure rate of perianal Crohn*s fistulas.
To evaluate whether a faecal calprotectin guided strategy of anti-TNF dosing interval lengthening is non-inferior in maintaining remission in patients with IBD compared with an unchanged dosing interval.
The primary study objective of our study is to assess the efficacy of an IFX intensified induction scheme vs. a standard dosing schedule in improving drug exposure (=therapeutic trough levels) without treatment escalation in pediatric CD patients.
The aim of this study is to investigate the efficacy of subcutaneous IFX in the treatment of moderate to severe Crohn*s disease with and without concomitant immunosuppression, as measured by the proportion of patients in corticosteroid-free clinical…
To compare PFS of patients with progressive, advanced, kinase inhibitor naïve, RET-mutant MTC treated with selpercatinib versus cabozantinib or vandetanib.
The primary objective of our study is to determine the efficacy and safety of top-down IFX treatment in moderate-to-severe pediatric CD. Secondary objectives are determination of the pharmacokinetic/-dynamic profile of IFX and finding predictors of…
Primary Objective: To study whether the pulse oximeter functionality of the wearable ear sensor is able to reliably measure oxygen saturation, pulse rate, and respiratory rate in a clinical (postoperative) setting.Secondary Objective(s): To evaluate…
To evaluate the tofacitinib and infliximab treatment-induced changes in plasma lipids and lipoproteins and to provide insight in the underlying mechanism in relation to the inflammatory status in patients with active UC.
To assess the concurrent validity of the FastFocus* Vital Sign Monitoring System classification algorithm that discriminates between lying, sitting/standing, and walking activities, and detects number of walking steps in hospitalised patients under…