6 results
Objectives:Primary Objective: to investigate the anti-tumor efficacy of domatinostat in combination with avelumab in advanced unresectable/metastatic MCC patients progressing on anti-PD-(L)1 antibody monotherapy.Secondary Objectives: to investigate…
The main objectives of this study is to evaluate if EGFR positive cervical lymph node metastasis can be detected non-invasively using the MSOT Acuity Echo with cetuximab-800CW as contrast agent in patients with oral squamous cell carcinoma.
The primary objective of this study is to examine the effectiveness of the use of a load-reducing orthosis for two months on functioning (using a validated osteoarthritis function questionnaire (WOMAC)) in ten patients with osteoarthritis of the…
Primary Objective: to evaluate clinical efficacy of domatinostat in combination with avelumab in treatment-naïve metastatic or distally recurrent MCC patients as determined by the Objective Response Rate (ORR) according to Response Evaluation…
The primary objective of this study is to investigate if an orthosis combined with exercise therapy results in less pain and less conversion to surgery than an orthosis alone in patients with CMC-1 OA at three months and one year after treatment…
Primary objectives: - To assess safety and feasibility of neoadjuvant nivolumab +/- domatinostat +/- ipilimumab- To identify pathologic response rates of nivolumab +/- domatinostat +/- ipilimumabSecondary objectives: - To describe all grade…