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Accelerated Pacing for Improved Quality of Life in Symptomatic Atrial Fibrillation Patients undergoing Pace-and-Abate Strategy with Left Bundle Branch Area Pacing: a Randomized Controlled Pilot Trial: PACE-AF

To determine the effect of accelerated pacing (lower programmed rate of 80 bpm) compared to pacing at the standard programmed rate of 60 bpm on HRQoL in symptomatic AF patients undergo-ing pace-and-ablate strategy with LBBAP.Secondary objectives: -…

non-responders of cardiac resynchronization therapy: the effect of left ventricular endocardial pacing and simulated exercise on acute hemodynamic response

This study evaluates the difference in response to CRT between endocardial en epicardial left ventricular pacing. Secondly, we will evaluate the effect of simulated exercise by means of intravenous dobutamine on response to CRT and device…

Differentiation between normal renal tissue and renal cell carcinoma using optical coherence tomography (OCT): a prospective human in-vivo study.

Demonstrate the ability of OCT to distinguish malignant renal tissue from benign (normal) renal tissue by means of attenuation-coefficient.

Right Atrial Pacing versus Left Atrial Pacing to Prevent Development of Paroxysmal Atrial Fibrillation in Patients with Sick Sinus Syndrome or Anti-arrhythmic Drug-induced Bradycardia.

- To determine the effects of the pacing site on prevention of AF episodes - To examine the relation between the pacing site, reduction of AF episodes, quality of life, heart failure, number of cardioversions, frequency and duration of hospital…

The influence of peroperative dobutamine infusion on the blood flow of the DIEP-flap

Primary Objective: To investigate in a prospective randomized controlled trial whether intravenous infusion of low doses dobutamine solely peroperative or for 18 more hours postoperative in women undergoing a breast reconstruction by means of a DIEP…

Postoperative sublingual microvascular blood flow following esophagectomy and the effect of dobutamine

- Primary Objective: to investigate whether the administration of a small amount of dobutamine postoperatively is able to positively influence the sublingual microcirculation in patients who are undergoing esophagectomy.- Secondary Objective: to…

Candidate Predictors of Changes in Heart function

The aim of the substudy is the identification of early (baseline) predictors of heart failure during a relatively high frequency of electrical stiumulation of the right ventricle. How does heart function change over a period of 2 years which…

Optimal cerebral perfusion after an extracranial-intracranial bypass: should we increase blood pressure or cardiac output?

We aim to study what the mean change in graft flow rate is when the cardiac output is increased with 10% and what the mean change in graft flow rate is, when the blood pressure is increased with 10% to enable further research to establish whether an…

Right ventricular contractile reserve and oxygen consumption in pulmonary arterial hypertension

To investigate the effects of Dobutamine on RV contractility and oxygen consumption in patients with pulmonary arterial hypertension (PAH).

Permanent left ventricular septal pacing versus right ventricular pacing in patients with atrioventricular conduction disorders: a randomized trial: LEAP trial.

The primary objective of this study is to compare in a randomized trial the effects of permanent LVSP with RVP in patients with a pacemaker indication because of AV conduction disorders, with respect to a composite of all-cause mortality,…