6 results
The objective of this study is to find the median local anesthetic dose (MLAD/ED50) of bupivacaine that allow direct post-operative mobilization and will accommodate sufficient anesthesia during surgery.Results from this study might lead to the…
The main purpose of this study is to assess whether the study drug anetumab ravtansine is more effective than treatment with vinorelbine in patients with stage IV, mesothelin overexpressing malignant pleural mesothelioma. Efficacy will be measured…
Main objective: - Evaluate the effect of itraconazole, a strong cytochrome P450 (CYP) 3A4 inhibitor and a P-glycoprotein (P-gp) inhibitor, on the safety and tolerability (including "thorough" electrocardiogram [ECG] assessment) and…
The key purpose of Safety lead in part of this study is to determine the maximum tolerable dose of anebumab ravtansine in combination with cisplatin for treatment of mesothelin-expressing cholangiocarcinoma, and similar for the combination with…
The objective of this study is to find the Median Local Anaesthetic Dose (MLAD/ED50) of Bupivacaine that allow direct postoperative mobilization and will accommodate sufficient anaesthesia during surgery.Results of this study might lead to…
Part 1 - To determine the efficacy of oral BCX9930 monotherapy administered for 24 weeks, compared to continued complement component 5 (C5) inhibitor therapy, in subjects with paroxysmal nocturnal hemoglobinuria (PNH) with an inadequate response to…