4 results
Primary objective:•To assess the effect of multiple dose daclatasvir (60mg QD) on the pharmacokinetics (AUC, Cmax, Ctrough, CLr) of multiple dose metformin (1,000mg BID) by intra-subject comparison, in healthy subjects.Secondary objective:•To assess…
Primary objectiveEvaluation of [18F]MC225 to measure the P-glycoprotein function in Alzheimer*s disease, Mild Cognitive Impairment and Parkinson*s disease. Secondary objectives1. Evaluation of blood-brain barrier integrity using [18F]MC225 and MRI…
The main objective of this study is to investigate gender differences in P-gp function at the blood brain barrier, in order to gain further insight into the impact of these differences on the action of pharmaceuticals (antidepressants and…
The primary objective of this study is to investigate the local tolerability of isoniazid inhalation by wet nebulization at ascending dosages. Secondary objective is systemic pharmacokinetics of inhaled isoniazid compared to intravenous dose…