234 results
To identify the patient profile for Actifuse and for other grafting products used to achieve bone fusion.
To determinate the efficacy and safety of golimumab in rheumatoid arthritis patients in daily clinical practice during 48 months. In addition, the effect of treatment with golimumab on the lipid profile will be monitored during this study.
(1) To investigate the effect of rTMS in a treatment set-up of 4 weeks including sham-rTMSas a control in 2 x 50 patients who have had at least two prior antidepressant therapies and psychotherapy according to the Dutch guideline of depression.(2)…
To evaluate the feasibility of the study after 20 weeks of follow-up, which includes the evaluation of the dose-reduction algorithm in tocilizumab-treated patients with RA.
1. To determine the proportion of patients developing anti-drug antibodies (ADA) detectable with an antigen binding test (ABT, radioimmunoassay) in patients experiencing inefficacy of their first TNF inhibitor treatment (phase 1).2. To study…
To determinate the efficacy and safety of certolizumab pegol in rheumatoid arthritis patients in daily clinical practice during 48 months. In addition, the effect of treatment with certolizumab pegol on the lipid profile will be monitored during…
- To investigate whether the effect of early-start rasagiline treatment (according to the ADAGIO study protocol) provided long term benefits over delayed-start.- To investigate the long-term effects of rasagiline in PD subjects who participated in…
To identify what might be the cause of the occurrence of diarrhea during the use of angiogenesis inhibitors sunitinib and sorafenib in patients with a malignancy.
The aim of this study is to investigate if conversion of tacrolimus-based immunosuppression to everolimus-based immunosuppression results in preservation of renal function as compared to continued tacrolimus-based immunosuppression. Apart from renal…
The main aim of the present study is i)To assess whether sugammadex has a positive effect on the post-operative alertness of the patients, and ii) to assess the nature, magnitude and the time of onset of this effect (if any).
Assessing the effectiveness and safety of parecoxib compared to placebo in pain relief children undergoing scoliosis surgery
The primary statistical objective of this study is to describe mean differences in corneal staining (type and area), for OPTI-FREE EverMoist Multi-Purpose Disinfecting Solution compared to baseline.
The primary objective is to measure the real-world daily activity in a representative cohort of 1100 longterm survivors after Ewing tumor treatment using portable devices, and to describe the functional outcome and health-related quality of life…
The 1st main objective is to collect detailed quantitative data on the everyday management of mRCC in the Netherlands, the clinical outcome of this management, as well as the resulting quality of life and financial costs. Treatment selection for…
Primary objectives* To evaluate the initial and long-term clinical results in terms of function, quality of life and pain/satisfaction of the Signature* procedure compared to the standard operation instruments (Vanguard CR cemented fixation).* To…
the objective of the current study is to evaluate the safety and efficacy of enzyme therapy in the Dutch population of patients with MPS I, II and VI; to compare this to the natural course of these diseases; to make an inventory of the direct and…
Primary:• To study the effect of rotigotine on nocturnal hypokinesiaSecondary:• To study the possibility of measuring nocturnal hypokinesia and its severity in a home setting• To correlate improvements in sleep quality by rotigotine with changes in…
In this present study we will assess the effect of a pre-warming intervention before surgery, in order to decrease the temperature gradient from core to periphery and thereby minimize redistribution hypothermia under anesthesia, on (I) the…
1. To detect subclinical cardiovascular damage in adults patients with breast cancer who have completed treatment with TAC at least one year previously at least one year previously, using MIBG scintigraphy, novel echocardiographic techniques and…
Are there differences is efficacy, side effects, tolerance en costs in patients with early RA in treatment with COBRA-light compared with COBRA according to BeSt?