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The longitudinal kinetics of long term cellular memory immunity against Bordetella pertussis in Dutch 8-9 years old children after ACV booster vaccination.

The assessment of the duration of the cellular immunity to Bordetella pertussis after an extra ACV booster and the relationship between the memory B- cells and antibody responses. The methods used in the study are:B- and T- cell memory responses and…

Influence of methylphenidate on sleep and circadian rhythm in children with Attention-Deficit/Hyperactivity Disorder (ADHD)

Determine the influence of methylphenidate treatment on sleep-wake rhythm and endogenous melatonin rhythm.

A Cross-sectional Study of Renal Function in Treatment-naïve, Young Male Patients with Fabry Disease

The objectives of this study are (1) to document renal function and other Fabry disease manifestations across age in treatment-naïve, young male patients with Fabry disease; and (2) to provide a reference group for comparison with interventional…

Immunological effects of an acellular pertussis booster vaccination in children, young adults and elderly with different immunisation background.
An international study in Finland, the Netherlands and the United Kingdom

Investigate the effects of aP booster vaccination in children, young adults and elderly on the (long-term) immune response to B. pertussis in three European countries with a different epidemiological background and primary vaccination schedule for…