322 results
The aim of this project is to evaluate the clinical value of biomarkers in adult patients with pulmonary hypertension, in particular:1) To quantify biomarkers of neurohormonal activity as NTproBNP, endotheline-1 and of immunological activity as CRP…
Systematic gathering of biomaterial and phenotypic data of IBD patients during clinical care provides assessment of molecular markers in the DNA, the transcriptome and proteome. The markers can be associated with the different disease phenotypes…
The aim of this study is to identify barriers and facilitators for successful implementation of the care pathway, to ultimately inform national scale-up of the pathway.
Investigate the effect of having CYP2C19 and CYP2D6 genotypes at start of antidepressant therapy and it’s cost-effectiveness in the primary care setting.
Our primary objectives are to determine the diagnostic accuracy of handheld RCM in the diagnosing and subtyping of BCC in the head and neck compared to punch biopsy, and evaluate the associated rate of over- and understaging of BCC subtypes. In…
Primary Objective To describe how patients experience the first eight weeks after shoulder arthroplasty, regarding pain and pain medication, shoulder function and quality of life. To determine the direct effect of patients' expectations on…
This multicentre randomised controlled trial aims to investigate whether PoCUS can be used as an adjunct to improve first attempt success rate in closed reductions of displaced distal radial fractures in adults in the ED.
MelanoScan
Rationale: Approximately, 10-20% of older adult patients present with non-specific complaints (NSCs) at the emergency department (ED). NSCs are known as poorly described symptoms, such as ‘weakness’ and ‘fatigue’, often leading to an extensive…
To determine: 1) How neuropsychiatrich problems change over time during the first year after stroke; 2) Which determinants are related to the course of neuropsychiatric problems over time during the first year after stroke; 3) What are the…
To determine the content validity and clinical utility of the Dutch sPCI according to nurses with expertise in stroke care and stroke patients, respectively.
We hypothesize that video consultations will be valued equivalent with F2F-visits, with a reduction in associated patient costs and total healthcare costs. In addition to that, we hypothesize that patients consider F2F-visits worth the effort and…
To establish the diagnostisch accuracy of ultrasound for the exclusion of fracture of the elbow
We hypothesize that sleep apnea screening, using a combination of an online questionnaire and high resolution overnight oximetry, can safely be applied to exclude sleep apnea with high sensitivity (≥97%) and acceptable specificity (≥60%) in patients…
Irregular heart rate can be detected with a camera-based monitoring technology.
The primary aim of this split-mouth randomized clinical trial is to assess accuracy of bracket positioning of a fully digital IDB workflow compared to a DBB workflow, with IDB bracket planning serving as reference for both methods. The secondary…
To evaluate the effectiveness of eccentric calf muscle exercise therapy compared to strength training of the upper extremities (control group) in patients with chronic midportion Achilles tendinopathy.
Mainstreaming of germline genetic tests in regular healthcare is feasible for healthcare professionals and acceptable for both patients and healthcare professionals
Vitamin C deficiency may play a role in the symptoms of patients with chronic kidney failure and eventually renal replacement therapy
PENG block with phenol provides better pain relieve and mobility, and therefore quality of life, compared to current pain relieve strategies in patients with a hipfracture who are not eligible for surgery