16 results
The primary goal is to demonstrate that in gastric esophageal cancer the addition of a microbiome intervention with fecal capsules from healthy donors can improve the effectiveness of perioperative chemotherapy as measured by the tumor regression…
This randomized phase II open label study examines the effect of controlled cooling versus no cooling on the incidence and severity of oxaliplatin-induced peripheral neuropathy (OIPN) in patients treated with oxaliplatin.
The main objective is to investigate the effect of a 16-week AET or CBT program on fatigue in patients with MG, compared to care as usual.
To determine safety, tolerability, and activity of individualized radioembolization with 166Ho-microspheres combined with FTD-TPI and bevacizumab.
To study the impact of tVNS on gut motor function, in particular with regards to its potential to induce phase III contractions in the upper GI tract, in healthy subjects.
The main objectives are to investigate whether our product is suitable for the target group, to identify barriers to wider implementation in mainstream care, and to gather patient experience and feedback. We want to know if patients perceive the…
The primary objective of this study is to compare efficacy of IRE to the efficacy of SBRT regarding the primary endpoint (local control at 2 years) in patients with perivascular and peribiliary CRLM (0-5 cm). The CRLM are unsuitable for surgery and…
Objectives:The main objective will be to assess whether treatment with nVNS, LXB or both interventions will increase the clearance of Aβ from the brain, compared to pre-treatment, in patients with CAA. Second objective is to study whether CAA…
To assess non-inferiority of treating patients with localized, intermediate risk prostate cancer in two fractions of 12 Gray (Gy) with a boost to the gross tumor volume of 13.5 Gy per fraction in 8 days, as compared to standard care (36.25 Gy in…
Transiently improve episodic memory in early AD patients with precuneal gamma (40 Hz) tACS (main objective) and identify what functional brain activity/network changes underlie this memory improvement (secondary objective)
The aim of this study is to determine whether cTBS treatment of the contralesional primary motor cortex leads to a reduction in contralesional inhibition from the contralesional to the ipsilesional motor cortex during movement onset.
The primary objective of this study is to assess the acceptability and feasibility of four-week, high-frequency rTMS and anodal high-definition tDCS of the DLPFC as potential intervention methods for the treatment of PD-MCI. Secondary study…
The PAPBI-3 trial is a phase I/II interventional trial assessing the toxicity and feasibility of repeat breast conserving therapy with preoperative partial breast irradiation in female patients aged 51 years or older with ipsilateral recurrent or…
The aim of the study is to investigate the effect of MDRT to the visible lesions in patients with omCRPC (up to 3 metastases and/or local recurrence) while continuing the ongoing systemic treatment. Progression is based on prostate specific membrane…
The primary objective:- To investigate the feasibility of capturing in-vivo cross section images of the bladder wall in bladder cancer patients with the OCT catheter.Secondary objectives:- To evaluate the duration of the OCT measurements. - To…
Primary: Can the number of online adaptive fractions be reduced by 30%?Secondary: What is the overall survival, local control, and toxicity? What is the movement of the bowel during treatment? Is there added value in re-aligning the patient when…