692 results
In the PROHTECT-3 trial, we offer hrHPV testing on self-sampled (cervico-)vaginal specimens obtained by a lavage device. The sensitivity and specificity for high grade CIN and cervical cancer (CIN2+/CIN3+) of two triage strategies of hrHPV positive…
There have been several studies that showed a possible positive effect of electrical stimulation on wound healing. One of the working principles is increasing blood flow. This could mean that by giving frequent electrical stimulation on the foot and…
We hypothesize that ingestion of potato protein increases muscle protein synthesis rates at rest as well as during recovery from exercise in young healthy males. We hypothesize that the muscle protein synthetic response to the ingestion of potato…
Evidence based medicine is the standard for current clinical practice. Guidelines and decision rules are developed to support medical decision making. Application of decision rules are supposed to improve efficiency and quality of care by early…
IPA as first-line therapy in the Emergency Department leads to: - faster initiation of symptomatic treatment for nauseous patients - more patients receiving symptomatic treatment for nausea - a decrease in the use of conventional anti-emetics - a…
Two-stage implant-based breast reconstruction is the most common reconstructive technique after mastectomy. It is associated with some implant specific complications such as capsular contracture. Capsular contracture is one of the most frequent long…
The scientific hypothesis of the present study is that supervised implementation of the guideline “Oral health care in (residential) care homes for elderly people” is more effective in improving oral health and oral health care of the residents when…
We expect brain activity and brain reactivity to change as satiation progresses. ROI are : Brainstem (dorsal vagal complex (DVC), nucleus tractus solitarius (NTS), parabrachial nucleus (PBN)), Hypothalamus, Insula, overlying operculum, secondary:…
In this project, a personalized EMA and feedback module, named Therap-i, is added to the treatment-as-usual (TAU) in patients with a depression diagnosis in tertiary care. The module is used to systematically self-monitor and reflect on momentary…
Flumazenil is a substrate of P-glycoprotein at the blood-brain barrier.
Aim of the MANCO study is to establish for once and for all that monitoring the effect of heparin during NCVI is essential to ensure the individual patient of safe and tailor-made anticoagulation. Not measuring the effect of the administered heparin…
Neutralizing antibody titers after fractional dosing of yellow fever vaccine are comparable to standard dose vaccination, ten years after primary vaccination
Our hypothesis is, that the extrinsic mechanism in the etiology of SIS is only valid for a subgroup of patients; complaints of SIS can be caused by 1) a pathologic pattern of arm-scapula movements caused by a disrupted balance in muscle forces,…
The primary objective of this clinical trial is to obtain pilot safety and efficacy data on treatment of PAH patients by 6-MP. The secondary objective of this clinical trial is to determine whether LEPs transcriptome analysis will identify a subset…
To test the safety and preliminary efficacy of a dual acute thrombolytic treatment consisting of a small intravenous (IV) bolus of alteplase followed by IV infusion of HisproUK against usual treatment with IV alteplase in patients presenting with…
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1. To determine the reproducibility and sensitivity of the Energy Cost of Walking test (ECWT) in boys with Duchenne muscular dystrophy, in comparison with the reproducibility and sensitivity of the 6-Minute Walk Test (6MWT); 2. To evaluate the 1-…
In primary prostate cancer patients, the exisstence of lymph node metastases is associated with developmment of distant metastases and negatively associated with cancer-specific survival. The performance of an extended lymph node dissection (ePLND…
A postoperative retransfusion system is most effective in terms of allogeneic blood transfusion rates when in situ for maximum of 6 hours after major orthopaedic surgery.
We hypothesize that exogenous, enterally provided glutamine contributes substantially to the de novo synthesis of arginine in critically ill patients.