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Reducing the amount of contrast medium in CTAs of the abdominal aorta using a multiphasic injection technique

Primary Objective: Is it possible to reduce the amount of contrast medium used in CTAs of the abdominal aorta by injecting the contrast medium with a multiphasic protocol, without losing image quality?Secondary Objective: What does the contrast…

The effects of interferon-gamma on sepsis-induced immunoparalysis, a randomised double-blind placebo-controlled pilot (Phase IIIb) study

The primary aim of this pilot-study is to assess safety and the effects on immune function in patients with septic shock of adjunctive therapy with IFN-gamma, in a placebo-controlled manner. The data obtained will allow us to do a powercalculation…

Pilot study: Is concomitant administration of lidocaine during oxaliplatin infusion able to prevent pain as a result of oxaliplatin induced acute neuropathy?

Primary objectiveTo evaluate the efficacy of low dose intravenously lidocaine in comparison with placebo in terms of pain relief after the first oxaliplatin administration measured by a numeric rating scale (NRS 0-10).Secondary objectives1.…

The value of Platelet-Rich Plasma in chronic midportion Achilles tendinopathy: a double-blind randomised clinical trial

To monitor the potential clinical improvement of treatment of tendon injuries with PRP and to evaluate the recovery process in time using the new UTC method.

Sensitization to lupine flour: is it clinically relevant?

We found a prevalence of 6% sensitization in patients with a possible food allergy. The aim of this study is to investigate if sensitization to lupine flour in atopic patients has clinical relevance. Additionally, we want to investigate if cross-…

Changes of Effective Downstream Pressure (EDP) and Cerebral Perfusion Pressure (CPP) under influence of hypnotics and volatile narcotics. A prospective, randomised, double-blinded trial.

Until now there has been a lack of investigations regarding the power of anaesthetics on the EDP.We will measure changes of EDP, CPPedp and autoregulation in each studie.- Study 1 : thiopental (5mg/kg) versus propofol (2mg/kg), - Study 2: etomidate…

Novel transcatheter arterial embolization for treatment of knee osteoarthritis: a randomized sham-controlled clinical trial

The main objective is to assess whether transcatheter arterial embolization of neovessels in patients with symptomatic knee OA results in significant pain reduction after 4 months compared to sham treatment.We hypothesize that novel transcatheter…

A Phase 3, Randomized, Double-blind Trial of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (KEYNOTE-641)

This study has been transitioned to CTIS with ID 2022-500785-10-00 check the CTIS register for the current data. 1) To compare pembrolizumab plus enzalutamide versus placebo plus enzalutamide with respect to overall survival (OS)2) To compare…

RedStroke- Reducing Europe's stroke incidence: Highly cost-effective population screening programs for Atrial Fibrillation coupled with high diagnostic yield confirmation services.;Multicentre, international, investigator-initiated, controlled, randomised, double-blind
clinical validation study of a smartphone application as screening tool
for differentiation between sinus rhythm and atrial fibrillation

To demonstrate that in patients with a CHA2DS2-VASc score of 2 or higher and no history of AF, the use of the Preventicus Heartbeats App increases the detection rate of AF compared to usual care and to demonstrate that AF screening with the app is…

Clinical Surveillance vs. Anticoagulation for Low-risk Patients with Isolated Subsegmental Pulmonary Embolism: A Multicenter Randomized Placebo-Controlled Non-Inferiority Trial

This study has been transitioned to CTIS with ID 2023-506943-40-00 check the CTIS register for the current data. The overall objective of this trial will be to evaluate the efficacy and safety of clinical surveillance without anticoagulation in low-…