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Randomized placebo-controlled pilot study to determine the effect of probiotics on vitamin K status in renal transplant recipients

To investigate the effect of a daily sachet of probiotics for 12 weeks vs placebo on vitamin K status in renal transplant recipients.

Pilot study on Ketosis Impact on Signs and Symptoms of Schizophrenia and Bipolar Disorders

The current pilot study intends to establish the effect of a single dose of dGK on relevant (neuro-)electrophysiological (primary outcome: Pre-Pulse Inhibition (PPI); furthermore on resting EEG, on the ERP P300, cognitive, metabolic, inflammatory,…

Acute effects of ketone monoester supplementation on brain function in older men with overweight

The primary objective is to evaluate in older men the acute effect of ketone monoester supplementation on (regional) brain vascular function and insulin-sensitivity, as quantified by the non-invasive gold standard magnetic resonance imaging (MRI)-…

PREBICC: Prebiotic intervention in patients with advanced colorectal cancer treated with 5-FU based chemotherapy: a randomized controlled clinical intervention study

This intervention study aims to investigate the effects of daily administration of a prebiotic fiber mixture in a Nutritionally Complete Oral Nutritional Supplement (ONS) for 8-9 weeks on intestinal microbiota composition and diversity in patients…

A randomized clinical trial to study positive effects of "T-REX Twente regimen" (Thoracic surgery Rehabilitation Experts Twente) on quality of life and mobilisation activities for cardiac surgery patients after full median sternotomy, compared to usual care

Do the T-REX Twente precautions have a positive impact on the quality of life (MAcNew QLMI), level of physical activity, and reduction of fear of movement in heart patients after a total median sternotomy compared to the (current) standard…

Prevention of diabetes with a novel butyrate-enriched triglyceride

Primary Objective:The main goal of the study is to investigate the effects of a chronic increase in the gut microbial metabolite butyrate and hexanoate in the systemic circulation on peripheral insulin sensitivity in individuals with overweight/…

Perioperative Lipofilling in Operative Treatment of Proximal Phalanx Fractures and Related Tenolysis: Improving Range of Motion

The aim of the two separate studies is as follows: 1. To evaluate the effect of perioperative micronised lipofilling in patients with ORIF of P1 fractures on postoperative range of motion2. To evaluate the effect of perioperative micronised…

Longer-term effects of wild blueberry consumption on brain function in older men and women

The primary objectives are to investigate in older adults the effect of 16-week wild blueberry consumption on (regional) vascular function and insulin-sensitivity in the brain, while we will also focus on changes in cognitive performance as assessed…

Effect of oat-coated disposable gloves compared to non-coated disposable gloves, in health care workers, with high glove consumption, on skin condition and user experience.

Usability of oat-coated gloves (intervention) and the effect on skin condition in comparison to non-coated gloves (care as usual).

Randomized, double-blind, sham-controlled trial to investigate combined occipital and supra-orbital neuromodulation in resistant migraine. The RECLAIM study.

To evaluate the safety and performance, including clinical benefit, of the PRIMUS System for the treatment of Resistant Migraine.

Personalized hemodynamic management targeting preoperative baseline cardiac index in high-risk patients having major abdominal surgery: the international multicenter randomized PELICAN trial

To investigate whether personalized hemodynamic management targeting baseline cardiac index reduces the incidence of a composite outcome of acute kidney injury, acute myocardial injury, non-fatal cardiac arrest, severe infectious complications, and…