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Intravenous immunoglobulin and prednisone vs. prednisone in newly diagnosed myositis: a double blind randomized clinical trial.

This study has been transitioned to CTIS with ID 2024-516057-42-00 check the CTIS register for the current data. The primary aim is to examine whether early addition of IVIg to standard treatment with prednisone in patients with newly diagnosed…

Randomized, double blind, mutlicenter, multinational, placebo controlled, single parallel escalating dose safety and efficacy study of ACT017 used as an add-on therapy on top of standard of care of acute ischemic stroke

The study primary objective will consist of assessing the safety and tolerability of single IV (bolus + infusion) doses of glenzocimab in patients with an acute ischemic stroke administered on top of the best emergency standard of care (including…

A PHASE 1, TWO-PART RANDOMIZED, ADAPTIVE DRUG-DRUG-INTERACTION STUDY TO EVALUATE THE SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF DERAMCICLANE AND DEXTROMETHORPHAN, ALONE AND COMBINED, IN HEALTHY ELDERLY SUBJECTS

In this study we will investigate how safe the new compound deramciclane is, when it is given alone and in combination with the existing medication dextromethorphan (Part B), and how well it is tolerated when it is used by healthy elderly…

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of BIIB059 in Adult Participants With Active Systemic Lupus Erythematosus Receiving Background Nonbiologic Lupus Standard of Care

This study has been transitioned to CTIS with ID 2023-505696-74-00 check the CTIS register for the current data. The primary objective of this study is to demonstrate efficacy of BIIB059compared with placebo in participants with active systemic…

A Double Blinded, Placebo Controlled, Crossover Infusion Study of Respiratory Pharmacodynamics of ENA-001 in Conjunction with Propofol, Hypoxia, and Hypercapnia

Primary Objectives:* To determine the safety and tolerability of ENA-001 in healthy subjects after low and high doses of ENA-001 under hypoxic and hypercapnic conditions in conjunction with low and high doses of propofol.* To determine the…

Randomized, double-blind, placebo-controlled study to characterize the immune response after repeated KLH immunizations in healthy volunteers

Primary To characterize systemic and local KLH-specific B and T cell responses by repeated KLH immunizationsSecondaryTo characterize the molecular basis of the KLH-driven skin response (acute versus delayed response, Th1 versus Th2 response)To…

Treating microalbuminuria over 24 weeks in subjects with or without type 2 diabetes or hypertension

To assess the albuminuria lowering effects of dapagliflozin in subjects with and without diabetes or hypertension and persistent elevated albuminuria.

Lactoferrin in the treatment of Long COVID

To reduce fatigue symptoms with the use of a bovine lactoferrin supplement in patients suffering from Long COVID.

A First-in-Human Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetic and Exploratory Markers of Efficacy for XAB05 in Healthy Subjects.

Primary objective:• To evaluate the safety and tolerability of single intravenous (i.v.) doses of XAB05 in healthy subjects.Secondary objective:• To characterize the plasma pharmacokinetic (PK) profile of single i.v. doses of XAB05 in healthy…

A randomised, double-blind, placebo-controlled, dose-ranging partial-block crossover study to investigate the effect of intravenous oliceridine on CNS functioning and nociceptive thresholds in healthy subjects, compared to morphine.

Primaryo To evaluate the effects of oliceridine following IV bolus dose administration on neurocognitive functioning, when compared to morphine and placeboSecondaryo To evaluate the effects of oliceridine following IV bolus dose administration on…

Effect of oral magnesium supplementation on insulin sensitivity in people with type 2 diabetes

To investigate the effect of oral magnesium supplementation on insulin sensitivity in people with T2DM and a low serum magnesium concentration.

A double blind, prospective, randomized, placebo controlled, multi-center phase 3 study to evaluate efficacy and safety of Cevira® in patients with cervical histologic high-grade squamous intraepithelial lesions (HSIL)

The purpose of the study is to evaluate the efficacy and safety of Cevira® compared to placebo in treatment of patients with cervical histologic HSIL.

Evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of topically applied NT-077 (tiotropium bromide) in healthy volunteers.

Primary objective: - To evaluate the systemic absorption and pharmacokinetics of topically applied NT-077 Secondary objectives: - To evaluate the safety and tolerability of topically applied NT-077- To evaluate the pharmacodynamic effect on sweat…

A RANDOMIZED, DOUBLE-BLINDED, DOUBLE-DUMMY, PLACEBO-CONTROLLED THOROUGH QTC STUDY WITH SINGLE ORAL DOSES OF CEDAZURIDINE IN HEALTHY SUBJECTS

The purpose of the study is to investigate the effect of cedazuridine on the values of specific electrocardiogram (ECG) parameters. One of these parameters is the QT -interval. The QT -interval indicates the recovery time of the heart muscle cells…

A multi-center, randomized, double-blind, placebo controlled study of ligelizumab (QGE031) in the treatment of Chronic Inducible Urticaria (CINDU) in adolescents and adults inadequately controlled by H1-antihistamines

The purpose of this study is to establish efficacy and safety of ligelizumab (QGE031) versus placebo in participants with chronic inducible urticaria who remain symptomatic despite treatment with H1 antihistamine.

A Phase 1 Study to Evaluate the Safety and Tolerability of BYON5667 Eye Drops in Healthy Subjects

Primary objective:* To evaluate the safety of BYON5667 eye drops.Secondary objective:* To evaluate the tolerability of BYON5667 eye drops.

Effect of citalopram on chest pain in patients with functional chest pain

To assess the effect of citalopram on symptoms of chest pain in patients with functional chest pain.

An RCT on cognitive bias modification for alcohol use disorders in a religion-based rehabilitation program

The present study aims to assess the effectiveness of a religion-adapted CBM intervention compared to a standard, non-religion CBM intervention, and sham intervention based on approach bias modification (ApBM).

Functional gait training as complementary treatment to botulinum toxin type A in patients with disabling dystonia due to Parkinson*s disease: a double-blind randomized controlled clinical trial.

To investigate whether treatment of dystonia causing varus tilt of the hindfoot in Parkinson*s disease is more effective when botulinum toxin type A is combined with complementary functional gait training compared to botulinum toxin type A treatment…

Cognitive and mood effects of a dietary supplement containing probiotics, vitamins and zinc: a randomized, double-blind, placebo-controlled crossover study in healthy humans.

To evaluate a probiotic formula, including selected strains able to produce neurotransmitters, vitamin D, B6, and zinc to provide new, safe and effective therapeutic option for:- Boosting cognitive performance- Prevent the onset of memory impairment…