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HIPPI shoulder - Hip-allograft In Proximal humerus fractures versus Plate Implantation alone: a randomized controlled trial

The aim of this RCT is to examine the differences in functional, clinical, and radiological out-comes, between LCP fixation alone and femoral allograft augmentation in addition to LCP. Ultimately, the purpose is to optimize treatment strategies and…

Laparoscopic versus robot-assisted left-sided pancreatectomy for benign and pre-malignant lesions (DIPLOMA-3): an international multicenter patient-blinded randomized controlled trial

To compare L-MILP with R-MILP for benign and pre-malignant lesions of the pancreas in high-volume centers, regarding:1. Peri- and postoperative outcomes in terms of COMPOS-panc left score, for non-inferiority2. Total hospital-related costs, for…

Deliver mOre aPplications for more durable Pulmonary vein IsOlation with the Pentaspline Pulsed Field Ablation catheter, the DOPPIO trial

to determine if freedom of AF may be improved by delivering more, and targeted PFA applications while avoiding side-effects of higher PFA dosing.

Effects of daily protein supplementation on brain function in older adults with overweight or obesity

The primary objective is to investigate in overweight or obese older adults the effect of daily protein supplementation for two weeks with either a plant-derived protein or an animal-derived protein on vascular function and insulin-sensitivity in…

Splintless versus conventional maxillomandibular advancement surgery for obstructive sleep apnea: a randomized controlled trial

The main objective is to investigate if splintless approach improve the surgical accuracy of MMA for OSA. The secondary objectives are to assess the effect of splintless MMA on duration of surgery, blood loss, adverse events, respiration function,…

Ring augmented versus standard gastric bypass: evaluating efficacy and outcomes

This study aims to compare outcomes between ring augmented RYGB (RaRYGB) using the MiniMizer and standard RYGB without a ring.

Why wait? (Cost)effectiveness of an online transdiagnostic therapy for patients and their loved ones

In the current study, we will analyze the (cost)effectiveness of an online, transdiagnostic positive psychology eHealth intervention for patients waiting for psychological out-patient treatment and their relatives. We expect that this intervention…

Tissue-level versus bone-level single implants in the posterior area, a randomized clinical trial

This study aims to evaluate and compare the long-term outcomes of tissue-level and bone-level single implants in the posterior region of the mandible or maxilla in patients with adequate bone for implant placement, with or without prior bone…

Are muscle characteristics associated with the effect of exercise training on muscle strength in rheumatic diseases and sarcopenia? - an explorative study
The Care for Muscle (C4M) Study

Primary Objective: To study the association between muscle characteristics (contractile, morphological,biochemical, and histological) and the response to high- and low-load exercise training on muscle strength in patients with rheumatoid arthritis (…

CATALYST: Cataract Surgery in Conjunction with Ab-interno Canaloplasty Compared to Cataract Surgery Only in Patients with Mild to Moderate Primary Open-Angle Glaucoma

To demonstrate the clinical efficacy and safety profile of canaloplasty utilizing the iTrackTM Advance canaloplasty device performed via an ab-interno surgical technique achieves:1. Enhanced IOP reduction at 12 months due to the techniques ability…

ARP versus SH

To assess and compare ARP to spontaneous healing in damaged sockets (>50% buccal bone loss) in the posterior mandible regarding the additional need for bone augmentation either prior to or during implant placement 4-6 months after tooth…