Search for a trial

Examining wheelchair skills of children who are propelling a manual wheelchair

To develop and examine the test-retest reliability of a wheelchair skills test for children

Increasing motor skills and physical activity in children with Developmental Coordination Disorder: a controlled trial.

To investigate the short-term and long-term effects of a 12-week motor skills intervention, including behavioural motivation techniques, on motor skills, physical activity, perceived motor competence and global self-worth in children with DCD.

The muscle activity of the diaphragm and intercostal muscles in acutely dyspneic children during hospitalization, before and after treatment with salbutamol

In the present study we want to examine the effect of salbutamol on the muscle tone of the diaphragm. We also want to examine the correlation between muscle tension measured by EMG and the Clinical Asthma Score. To include the children that come to…

Combined PSGand HRM-MII measurement to assess the relation between gastroesophageal reflux and apnea in infants

Determine the existence of a relation between GER and apnea and their underlying mechanisms, in infants *37 weeks * 12 months.

Palatability testing of a new paediatric formulation of valacyclovir for the prophylaxis and treatment of VZV and HSV infections in children - VALID 0

PrimaryTo determine whether the palatability of a newly developed formulation of valacyclovir is non-inferior to administration of crushed and suspended tablets in children, is the primary objective of the second phase of the trial.The primary…

Oridispersible Minitablets of Enalapril in Children With Heart Failure due to Dilated Cardiomyopathy (WP08 Trial)

Primary:To obtain paediatric pharmacokinetic data of enalapril and its active metabolite enalaprilat in paediatric patients treated with enalapril ODMTs to describe the dose exposure in the paediatric population with DCM.Secondary:1. To demonstrate…

Development of individual therapy for cystic fibrosis using primary epithelial tissue cultures

The overall aim of the study is to improve diagnostic and therapeutic options for people with CF, especially in the context of young children and novel CFTR-targeting drugs. Primary Objective: 1. to demonstrate relations between CFTR genotype,…

Effects of propofol on microcirculation in children

To obtain intermittent buccal and continuous sublingual microcirculatory profiles by sidestream dark-field imaging before and after induction of propofol by non-invasive diagnostics in infants and children.

A Phase I/II, open-label, dose escalating with 48-week treatment study to assess the safety and tolerability, pharmacokinetics, pharmacodynamics and efficacy of BMN 053 (previously knoen as PRO053) in subjects with Duchenne muscular dystrophy

Primary objective: To assess the efficacy of BMN 053 at recommended dosing regimen after 48 weeks treatment in ambulant subjects with Duchenne muscular dystrophy.Secondary objectives: - To assess the safety and tolerability of BMN 053 after single…

An explorative prospective observational case-control pilot of EEG registration of cortical spreading depression in patients aged 4 years or older, with an acute migraine attack admitted at the headache outpatient service of Medisch Spectrum Twente

Primary Objective: To measure cortical spreading depression with full-band EEG during the migraine attack at patients aged 4 years or older. Secondary Objective(s): -To explore (additional) signal analysis techniques for detecting CSDs or infra slow…

A novel genetic cause of congenital central hypothyroidism.

Primary objective1) To study the frequency of mutations in this gene in patients with central hypothyroidism and their first- and second-degree relativesSecondary objective: 2) To determine the clinical, biochemical and radiological consequences of…

A phase IIb, open-label study to assess the efficacy, safety, pharmacodynamics and pharmacokinetics of multiple subcutaneous doses of BMN 045 (previously known as PRO045) in subjects with Duchenne muscular dystrophy

Primary objective:To assess the efficacy of BMN 045 after 48 weeks treatment in ambulant subjects with Duchenne muscular dystrophy.Secondary objectives:To assess the safety and tolerability of BMN 045 after 48 weeks of treatment in all study…

Paediatric distal radius torus fracture treatment comparison in a prospective randomized control trial: mitella versus plaster cast

If the study shows that the treatment with a sling gives an earlier return to normal function en does not give a clinically significant difference in pain experience compared to cast therapy than the traditional treatment can be adjusted. We aim at…

Optical coherence tomography in non-syndromic craniosynostosis patients

The primary objective is to obtain OCT data for children aged 4 to 10 diagnosed with non-syndromic craniosynostosis and to compare these to the normal reference values.

Response to DDAVP In mild Hemophilia A patients, in Search for dEterminants

The aim of this project is to investigate the association between clinical and genetic factors and DDAVP response in MHA patients and to determine their relative contributions to the DDAVP response.

Dietary treatment of children with Angelman Syndrome and refractory epilepsy

Primary objective: - 50% seizure reduction or more at 3 months of dietary treatment .Secondary objectives: -level of ketosis on KD and MAD.-number of patients maintaining >50% seizure reduction on MAD.-number of withdrawals (not able to…

An open-label extension study of the long-term safety, tolerability and efficacy of drisapersen in subjects with Duchenne Muscular Dystrophy.

The purpose of this study is to assess the safety, tolerability and efficacy of long term drisapersen in subjects with DMD.

Identification of novel childhood osteosarcoma predisposing genes.

To identify novel childhood osteosarcoma predisposing genes.

Biomarker-guided treatment-and-stop-strategy for recombinant IL-1receptor antagonist (anakinra) in patients with systemic Juvenile Idiopathic Arthritis.

This study has been transitioned to CTIS with ID 2024-518684-35-00 check the CTIS register for the current data. The current project proposal continues on our findings of the performed prospective cohort study, aiming to develop a biomarker guided…

ADOLESCE-NT: More rapid deterioration of renal function after renal transplantation in adolescence: effect of the endocrine system on immunological and pharmacokinetic factors

Answering the question if there are any associations between hormonal status in adolescence on the one hand, and immunological reactivity and pharmacodynamics on the other hand; and if such associations can explain the more rapid deterioration of…