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Comparison between Direct Oral Anticoagulation (DOAC) Interruption and DOAC Continuation in Patients Undergoing Elective Invasive Coronary Angiography or Percutaneous Coronary Intervention

The aim of our study is to study the safety of continued DOAC use during ICA or CAG in elective procedures, by comparing the risk of in-hospital and 30-day bleeding complications between continued and interrupted DOAC use.

Multi-parametric MRI in patients suspected for muscle invasive bladder cancer: a new local staging paradigm

The aim of this study is to determine whether multiparametric MRI (mpMRI) of the bladder, in combination with an outpatient biopsy for histological confirmation, is a faster, safer, cheaper and therefore more cost-effective way to detect or…

High Flow Nasal Oxygen For Hypercapnic, Acidotic Exacerbation Chronic Obstructive Pulmonary Disease. (HicaP)

To assess the feasibility of a larger study comparing HFNO with NIV as first line treatment in hypercapnic, acidotic AECOPD.

FiberUP

To investigate the feasibility of increasing preoperative dietary fiber intake in CRC patients undergoing surgery via 1) personalized dietary advice (Vezel-UP tool), or 2) vegetable product containing natural fibers (WholeFiber) compared to 3)…

LIMited wEdge ResectIon for Colonic T1 cancer - a prospective multicenter cohort study

The aim of this study is to investigate the safety and efficacy of CAL-WR as primary and curative colon-preserving treatment for T1 colon cancer. Our primary endpoint is reduction of oncologic resections for low-risk T1 colon cancer. As secondary…

An interventional, prospective IVD device study for the testing of DNA extracted from tumor tissue biopsy samples in a first line setting from patients diagnosed with metastatic Colorectal Cancer (mCRC) to determine the KRAS G12C mutation status as part of the inclusion criteria into the Amgen Phase III clinical trial (Protocol No 20210081) to demonstrate clinical performance of the therascreen® KRAS RGQ PCR Kit.

To utilize the therascreen KRAS RGQ PCR Kit, as a screening test in Amgen*s Phase 3 Clinical Study Protocol 20210081, in order to identify patients with mCRC KRAS G12C mutation positive tumors to be enrolled in the drug clinical trial. Results of…

BiOmarkers tO perSonalise Treatment of depression (BOOST depression)

Our primary objective in this study is to predict treatment outcome for SSRI, CBT, rTMS, esketamine, and ECT in patients with MDD with the use of biomarkers and machine learning using data obtained before a new or follow-up treatment. Our secondary…

Study to Assess How Well a Laboratory Test Measures Levels of a Specific Marker in Lung Cancer Samples from a Clinical Trial

The primary objective of this study is to evaluate the clinical performance of the VENTANA PD-L1 (SP263) CDx Assay in terms of its ability to identify patients with non-squamous stage IV or recurrent NSCLC who may benefit from treatment with…

In Vitro Diagnostic Clinical Performance Study Plan to determine HER2 and PD-L1 status of HER2-positive gastric cancer specimens.

Supplement to Clinical Study Protocol: D702AC00001 (Artemide-Gastric01)

To support the AstraZeneca ARTEMIDE-Gastric01 clinical trial by testing for PD-L1 and HER2 expression in FFPE tumor specimens for eligibility and stratification.The primary objective of this clinical performance study is to evaluate the…