43 results
To determine the real world response to standard of care CAR T-cell therapy, in order to better understand the intrinsic and extrinsic factors related to treatment success or failure.
To evaluate the feasibility, safety and potential efficacy of acupuncture in children with FC. The results of this study will be used to design a future randomized controlled trial (RCT).
Primary Objective: Compare visual acuity between adults born prematurely and adults of general population born at full term.Secondary Objective(s): o Compare other anatomical and functional ocular outcomes (retina, macula thickness, refraction,…
In this proposal, we will collect samples from both US and international corneal ulcers, identify etiology, AMR, and local host immune response, and correlate with presentation and outcome.Specific Aim 1. Worldwide surveillance of organisms…
We aim to collect blood cells from 40 patients with monogenic epilepsy, with a preference for patients with a pathogenic variant in SCN1A, reprogram these cells into iPSCs and use these iPSCs for differentiation into neurons and neuronal organoids…
In this study, we are looking at the effectiveness of following phase 3, the maintenance phase, of the Crohn's Disease Exclusion Diet (CDED) compared to normal diet (with or without standard maintenance treatment) in children and adults with…
The primary objective is to identify clinical and biological measures that discriminate paediatric ME/CFS and post-COVID patients from healthy controls based on either clinical (based on physiological tests and questionnaires) and biological (based…
The objective of this study is to characterise and validate multidimensional latent risk and resilience mental health trajectories in a trans-syndromal sample of help-seeking young people, including identifying genetic, environmental, biological,…
Primary: To describe shoulder function, local fatigue and pain symptoms around the shoulders in children with FSHD type 1, before and after balanced shoulder therapy. Secondary: To gain insight into the experience of children and parents and the…
To investigate whether TLND can be safely omitted in patients with macroscopic resectable stage III (B/C/D) melanoma achieving an MPR within the ILN upon neoadjuvant treatment with nivolumab in combination with ipilimumab.
To elucidate whether reducing glycemic variability with hybrid closed-loop therapy inhibits the inflammatory response (e.g. leukocyte phenotype, cytokine production, inflammatory proteins) in people with T1DM. Our secondary objectives are to…
We aim to identify if pediatric PAH patients have increased plasma IL-1β and IL-18 compared to control participants, as well as increased caspase-1 cleavage and NLRP3, IL-1β and IL-18 mRNA expression in PBMCs, reflective of inflammasome activation.…
The primary aim is to determine the length of hospital stay after trauma in patients admitted with one or more rib fractures, who used versus who did not use the Breazy app. The secondary aims are to determine: 1) rate of pneumonia within 30 days; 2…
The aim of this study is to develop a Dutch adaptation and translation of the User Satisfaction Evaluation Questionnaire (USEQ), for measuring user satisfaction and usability in a Dutch pediatric population (6-18 years old), and to determine its…
The primary objective of this study is to evaluate the diagnostic accuracy of physical examination and ultrasound to identify active synovial proliferation in haemophilia patients with subclinical synovial proliferation. The secondary…
Therapeutic nadroparin administration:Primary objective: To develop evidence-based dosing regimens of nadroparin for children in different age groups by means of the objectification of the PK/PD of nadroparin.Secondary objective: 1) Investigate the…
The primary objective is to explore the effect on Donning and Doffing of REACTION and their subsystems (ABLE REGAIN and GABLE CORE) in individuals with neurological disorders. The secondary goals include: 1. To explore the effect of REACTION and…
Our primary objective is to collect normative reference values in typically healthy developing children, aged 0 - 18 years, for EEG in combination with ERP and eyetracking, and OCT measurements (For details see also paragraph 5.1).
The aim of this study is to determine whether this smart wristband can actually support patients and their parents in managing the consequences of hypothalamic dysfunction. We will investigate what kind of support patients, parents, or caregivers…
The main objective of this study is to observe current AE treatment strategies and the treatment response of these strategies after 2 weeks in several hospitals. Secondary objectives are (1) to measure effect treatment on FeNO, eosinophils and…