180 results
The primary objective is to develop algorithms that define digital biomarkers for disease progression in Progressive Supranuclear Palsy patients. The biomarkers, when developed systematically, can eventually serve as primary or secondary clinical…
Primary Objective: To investigate the efficacy and safety of octreotide treatment (a somatostatin analogue) in decreasing the transfusion requirements (IV iron infusions and / or red blood cell transfusions) in patients with GI bleeding caused by…
to test the feasibility of the study protocol for operability, intensity and logistics and to test whether the chosen activities can be measured as expected, in order to provide a guideline for testing maximum aerobic capacity and the metabolic…
To demonstrate superiority of left ventricular septal pacing over right ventricular pacing and to investigate the additional effect of capturing the left bundle branch in left ventricular septal pacing (LVsP). This will be done by studying…
The main objective of the project is to study difference between compliance by pill count after 3 months by newly diagnosed multiple myeloma (NDMM) patients with an innovative e-coach, in order to improve treatment compliance by the intervention…
The main objectives of this study are(I) to compare the sensitivity of CT-venography and ultrasound for screening-detected, catheter-related thrombosis in cancer patients and (II) to assess intrinsic coagulation levels in cancer patients prior to…
Primary objective is assessment of the pharmacokinetic profile of MPD in pregnancy. Secondary objectives are the safety and efficacy of any use of MPD during pregnancy.
The main purpose of this study is to investigate the effect of ASTX660 on how quickly and to what extent quinidine and fexofenadine are absorbed, distributed, broken down and eliminated from the body. Quinidine and fexofenadine have been chosen…
To evaluate the relative oral bioavailability and dose proportionality of concept formulations compared with the reference formulation of aticaprant when administered in healthy adult participants. This part will be conducted by PRA.To evaluate the…
To test the first feasibility and safety of intratumoral 166-holmium microspheres implantation in pancreatic cancer in a controlled, open-surgery setting.
In this study we will investigate how quickly and to what extent the new compound JNJ-67856633 is absorbed, transported, and eliminated from the body. JNJ-67856633 is radioactively labelled with carbon-14 (14C).We also investigate how safe JNJ-…
The study includes 2 periods, Period 1 and Period 2. Subjects will participate in both periods. Period 1:The purpose of Period 1 is to investigate how quickly and to what extent enpatoran is absorbed, transported and eliminated from the body (this…
To investigate if the pre- and/or postoperative 3D-HRAM and 3 dimensional endo-anal ultrasound (3D-EAUS) might be a predictor for fecal incontinence after fistulotomy by evaluating changes in anorectal function and correlate this with the Fecal…
The main objective of this study is to validate the accuracy of the device to monitor the physical activity of a subject by comparing the measured values to the golden standard (video recording).
The primary objective of the present study is to determine the accuracy of the Philips health band for the assessment of total energy expenditure in recreational athletes, in patients with chronic heart failure and patients with coronary artery…
To investigate whether online mindfulness-based stress reduction (MBSR) therapy and an aerobe training intervention both leading to stress reduction and reduced circulatory risk in formerly preeclamptic women with increased mental stress levels…
The purpose of this study is to investigate how quickly and to what extend lenalidomide is absorbed and eliminated from the body (this is called pharmacokinetics). In this study the pharmacokinetics will be compared when lenalidomide is administered…
The primary objective of this study is to compare cholinergic innervation of the cerebral cortex of GBA-PD and non-GBA-PD patients, using [18]FEOBV PET imaging of the brain.
Through this research, we want to further investigate the concept of ear molding through the use of the EarWell Infant Corrective System, this time in the Dutch population. We hope to investigate the opinion on the treatment within the Dutch…
This study aims to investigate the progression-free survival (PFS) according to RECIST 1.1 criteria on matched targeted therapy by STA-analysis (PFS2) in comparison to the PFS recorded on the therapy administered immediately prior to enrolment (PFS1…