124 results
The primary objective is to establish whether prefrontal compensatory mechanisms during working-memory performance may be enhanced by working-memory training, both in healthy older adults and MCI patients. The secondary objective is to establish age…
We hypothesize a lung*protective mechanical ventilation using lower tidal volumes during general anesthesia for minimally invasive transthoracic esophagectomy to protect against postoperative pulmonary complications in patients undergoing minimally…
We want to describe in detail the MTH-induced changes in pro- and anti-inflammatory markers in patients after CA. We further aim to evaluate the relation between neurological outcome and levels of pro- and anti-inflammatory markers.
To investigate the dynamic changes in bone marrow adiposity during the menstrual cycle as assessed by Dixon*s Quantitative Chemical Shift Imaging (QCSI) measurements and to determine the role of estrogen in these changes.
PrimaryTo determine whether the palatability of a newly developed formulation of valacyclovir is non-inferior to administration of crushed and suspended tablets in children, is the primary objective of the second phase of the trial.The primary…
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The aim of this study is to find possible biomarkers (predictive or prognostic) for the treatment of patients with advanced renal cell carcinoma. This will require that changes in the tumor and peripheral blood components are studied before and…
In this study we aim to gain more insights into immune reconstitution of various leukocyte populations after SCT. By application of heavy water labeling we investigate if and how the production- and death rate of leukocytes changes after an SCT.
In Phase 1 of the project, a systematic approach will be used to identify which factors add to the prediction of children*s clinical risk status. First, we will determine how well multiple assessments of behavioral problems (opposition, aggression,…
Primary Objective: Is there an effect of DBS on eye movements?Secondary Objective: Are there different effects of DBS on eye movements by targeting different structures in the brain?
The aim of the study is to compare the treatment with four or six implants in combination with an overdenture for patients with lack of retention and stability of their complete upper denture.The clinical function of the implants and overdenture,…
Previous investigations in our lab have provided insight in the requirements for development of such a system and shown the feasibility of the paradigm (Blokland et al., 2011). We have been able to optimize the settings of our proposed system to…
To determine whether surgery induces changes in the liver vasculature of patients with colorectal cancer.
In this study we want to investigate if the muscle-relaxation time (muscle-RT), calculated from force profiles obtained with two different experimental methods (1) voluntary handgrip- and (2) peripheral nerve stimulation myometry, is a reliable and…
The primary objective of this study is to validate the use of a zero-heat flow temperature sensor for the measurement of core body temperature in the NICU by comparing it with 2 other modalities for core temperature measurement.
The primary objective of the study is to validate the use of a reference tissue model and an image derived input function for the quantification of estrogen receptors in the human brain, by [18F]FES PET. The secondary objective is to determine…
At the stroke unit, exposure to the *Dynamic Adaptive Healing Light System* (DAHLS) following a predefined daily rhythm with low, medium or high intensities dependent of the medical status of the ischemic stroke patient is expected to improve the…
To determine whether a difference in resilience of inflammatory tone between healthy and prediabetic males can be identified with whole blood ex vivo LPS stimulation.
The main objective of the study is to investigate whether natural elements and/or daylight can produce measurable beneficial effects on mental health * in particular mood, vitality, stress relief and self control strength * during the course of the…