17 results
the application of EMDR therapy is associated with a significant decrease in severity of depressive symptoms and decrease of percentage of patients meeting DSM-5 criteria for MDD compared to the waiting list. Participants receiving EMDR report after…
The primary objective of this study is to establish molecular profiles in lower rectal biopsies as close to the internal fistula orifice tissue and fistula scrapings based on single cell RNA sequencing, cellular protein expression by CyTOF and…
The primary objective is to explore whether central sensitization and/or abnormal CPM responses are present in (a subgroup of) patients who will receive shoulder arthroplasty for osteoarthritis, and whether shoulder arthroplasty produces change in…
The main objective of this study is to determine whether tubal flushing with oil-based contrast during HSG results into more pregnancies leading to live births when compared to tubal flushing with ExEm-foam during HyFoSy, and whether this approach…
The goal of the current observational multicenter pilot study is to investigate if an 8-week Acceptance and Commitment group therapy for youth with ASD is an effective intervention to increase adaptive emotion regulation, psychological flexibility…
In the RAINBO POLEmut-BLUE trial, omission of adjuvant therapy will be investigated in very low risk disease and de-escalation of treatment (observation or radiotherapy, but not chemoradiation) in low risk disease.
Primary Objective: To assess the add-on effect of the EMD-U treatment compared to CAU, in improving dermatology-specific quality of life in patients with atopic dermatitis or prurigo nodularis who suffer from severe scratching behaviour. Hypothesis…
Overall objective:To improve the existing drug prescribing and treatment monitoring process.Objective appendix 1: To prospectively evaluate the predictive performance of the MIPD strategy for tacrolimus and mycophenolic acid in paediatric patients…
This study will consist of three parts with three different main objectives:- Part 1 - Pilot study; Primary objective: To assess and compare thermal comfort upon wearing a cooling vest, based on exposed cooling packs versus…
Our aim is to develop JITAIs focused on behavioral activation (BA) for depression in close collaboration with patients and therapists, and to examine their usability, feasibility, and preliminary effectiveness.
The primary objective of this study is to evaluate the (cost-)effectiveness of ET for late-life anxiety disorders delivered by trained MHNs in primary care, in terms of anxiety and quality of life, compared to UC. UC is not restricted, and the GP…
The purpose of this clinical study is to evaluate the safety and clinical efficacy of the VDyne System in the treatment of moderate or greater TR.
rTMS is an intensive but effective treatment that could benefit from further optimization. Cognitive control training (CCT) engages the same underlying neural circuitry as rTMS and has been shown to improve therapeutic response (Koster et al., 2017…
Main objectives:a) examine and assess the (cost-)effectiveness of WHO's Doing What Matters in Times of Stress (DWM) in reducing psychological distress, improving mental health, and enhancing work-related well-being and…
Primary objective: To assess whether a psychoeducational and peer-support-based intervention improves self-efficacy in individuals with neurovascular conditions. Secondary objectives: To examine the intervention’s effects on quality of life (QoL),…
Through a randomized-controlled trial, we aim to investigate the effect of a growth mindset intervention for children with dyslexia on the effectiveness of their dyslexia treatment. Our primary hypothesis is that children who have received the…
In this explorative study, we aim to: Analyze neoantigens expressed on different tumors of CMMRD patients, to identify more possible target antigens for DC vaccination studies and to select the antigens that are most frequent. …