42 results
The aim of this project is to evaluate the clinical value of biomarkers in adult patients with pulmonary hypertension, in particular:1) To quantify biomarkers of neurohormonal activity as NTproBNP, endotheline-1 and of immunological activity as CRP…
The objectives are firstly that Love is... promotes the healthy sexual development by increasing knowledge and positive attitudes towards sexuality. Secondly, characteristics of adolescents who do not improve from the general prevention program are…
Development of new imaging techniques for MR-guided motion management in the presence of respiratory motion
To study patients with clinically suspect arthralgia in order to 1) develop diagnostic/prognostic markers (a. markers of systemic and b. local inflammation as well as c. autoantibodies) for the development of RA 2) to improve the mechanistic…
1A) To implement a screening-protocol for HIV related co-morbidities and their risk factors, based on multidisciplinary expert consultation, in a large HIV outpatient clinic and among an HIV-uninfected control group.1B) To assess the prevalence and…
The primary objective of this study is to establish molecular profiles in lower rectal biopsies as close to the internal fistula orifice tissue and fistula scrapings based on single cell RNA sequencing, cellular protein expression by CyTOF and…
To evaluate whether we can determine the health status of the joint by measuring biomarker levels using a newly developed assay by the University of Twente based on the multiplex measurement of a panel of relevant biomarkers using Surface Plasmon…
Primary Objective: 1. To compare total testosterone levels between male CCH and ECH patients and healthy controls To compare total testosterone levels in males with ECH during remission (remission ECH) and during an active…
Primary objectives:1) Investigate the effectivity of PRIMARY on BPD related problems (especially self-harm, emotion regulation and social relationships)Secondary objectives:1) Understanding the underlying mechanisms (especially social relationships…
The primary objective is to investigate if the stress-induced dynamics across stress systems are impaired in patients with CT-related depression compared to non-CT-related depression and healthy controls. The secondary objective is to examine how…
The first aim of this study is to use an in vitro approach using patient's derived material to accurately and rapidly predict the optimal therapeutic approach that will predict a good clinical response in individual patients…
Primary Objective: Primary: Gut microbiota (oral and fecal) and nasal microbiota composition in relation to autoimmunity status (antibodies (ANA, ANCA) and HLA subtype) and inflammatory functional assays as well as disease&…
1. To study the possibility to detect gynaecological malignancies and endometriosis in vaginal self-swabs, Pap smears and blood of women with gynaecological cancer or endometriosis, using MeD-seq and MeD-scan assays, in order to develop…
The primary objective is to evaluate longitudinal developmental changes in brain structure in patients aged 6-18 years with SCD. The secondary objective is to analyze the longitudinal relations between biomarkers, demographic characteristics, brain…
To develop a prediction model for BPD using a range of multimodal predictors assessed in the first two weeks of life.
To establish the test-retest reliability of the 13C-PBT for measuring Phe hydroxylation in patients with PKU.
The primary objective is to assess diagnostic accuracy of MRDTI/BTI for first and recurrent CVT in patients referred for MRI/MRV in the setting of routine clinical setting. The secondary objectives are to optimize MRDTI/BTI sequences for imaging…
To evaluate in SSc patients with low risk for disease progression 1) whether assessment in an outpatient clinic setting is an acceptable alternative for evaluation in the Care Pathway. Outcome parameters we will evaluate include 1) health care…
To investigate whether high perceived stress is associated with inflammatory reprogramming of innate immune cells and their bone marrow progenitors, and with increased arterial wall inflammation, in subjects with an increased CVD risk.
In this study, we therefore aim to investigate how trained immunity is systemically regulated in kidney transplant patients and how the degree of trained immunity affects graft survival in patients. A better understanding of these processes…