Search for a trial

Effectiveness of EMDR for adolescents with Major Depressive Disorder

the application of EMDR therapy is associated with a significant decrease in severity of depressive symptoms and decrease of percentage of patients meeting DSM-5 criteria for MDD compared to the waiting list. Participants receiving EMDR report after…

A pilot study of Acceptance and Commitment Therapy (ACT) for adolescents with autism spectrum disorder (ASD)

The goal of the current observational multicenter pilot study is to investigate if an 8-week Acceptance and Commitment group therapy for youth with ASD is an effective intervention to increase adaptive emotion regulation, psychological flexibility…

The effect of the EMD protocol for urge compared to care as usual on dermatology-specific quality of life

Primary Objective: To assess the add-on effect of the EMD-U treatment compared to CAU, in improving dermatology-specific quality of life in patients with atopic dermatitis or prurigo nodularis who suffer from severe scratching behaviour. Hypothesis…

Dolphin CONTINUE: A nutritional intervention aimed at improving neurodevelopmental outcome in infants at risk for or with early life brain injury

The main objective is to study the effect of the nutritional intervention versus the control product on white matter development (as assessed using tract based spatial statistics of fractional anisotropy) using a DTI scan at the corrected age of…

Defeating Fear with Exposure therapy delivered by mental health nurses in primary care for Anxiety Disorders in older adults - a cluster-randomized controlled trial

The primary objective of this study is to evaluate the (cost-)effectiveness of ET for late-life anxiety disorders delivered by trained MHNs in primary care, in terms of anxiety and quality of life, compared to UC. UC is not restricted, and the GP…

Enhancing effect of dual interventions versus conventional TMS in the treatment of
depression

rTMS is an intensive but effective treatment that could benefit from further optimization. Cognitive control training (CCT) engages the same underlying neural circuitry as rTMS and has been shown to improve therapeutic response (Koster et al., 2017…

Explore Your Brain - Dyslexia

Through a randomized-controlled trial, we aim to investigate the effect of a growth mindset intervention for children with dyslexia on the effectiveness of their dyslexia treatment. Our primary hypothesis is that children who have received the…

Improving the mental health of working adults in Dutch small-to-medium-enterprises (SMEs): implementation of WHO*s Doing What Matters in times of stress (DWM)

Main objectives:a) examine and assess the (cost-)effectiveness of WHO's Doing What Matters in Times of Stress (DWM) in reducing psychological distress, improving mental health, and enhancing work-related well-being and…

Effects of butyrate on depressive symptoms and affect in depression - a pilot randomized controlled trial

The primary objectives are to study the feasibility and acceptability of an 8-week daily oral supplementation with tributyrin (4 g/day) - the triglyceride form of butyric acid - on top of treatment as usual (TAU) in adults (18 up to 65 years) with…

The RECOGNISE Study: Neuropsychological Rehabilitation for Emotional and Cognitive consequences After Neurovascular Diseases

Primary objective: To assess whether a psychoeducational and peer-support-based intervention improves self-efficacy in individuals with neurovascular conditions. Secondary objectives: To examine the intervention’s effects on quality of life (QoL),…