22 results
1A) To implement a screening-protocol for HIV related co-morbidities and their risk factors, based on multidisciplinary expert consultation, in a large HIV outpatient clinic and among an HIV-uninfected control group.1B) To assess the prevalence and…
The primary objective of this study is to establish molecular profiles in lower rectal biopsies as close to the internal fistula orifice tissue and fistula scrapings based on single cell RNA sequencing, cellular protein expression by CyTOF and…
To examine the prevalence, risk factors and mechanisms of impaired health outcomes (short- and long-term medical and psychosocial effects and late effects) over time among a population-based sample of AYA cancer patients.Primary Objective: - To…
Primary objective1. The primary aim of the study is to answer the question whether specification of a positive direct antiglobulin test and/or red blood cell autoantibody specification is correlated with the clinical course in patients with AIHA.…
Primary objective: to register and investigate Dutch patients suspect for an inherited platelet function disorder, to assess clinical presentation, bleeding score, treatment, burden of disease and quality of life. Secondary objectives: to…
The primary objective is to investigate if the stress-induced dynamics across stress systems are impaired in patients with CT-related depression compared to non-CT-related depression and healthy controls. The secondary objective is to examine how…
Primary objectives: - To examine how environmental exposures influence the prevalence, 5-year incidence and progression of cardiometabolic and chronic respiratory disease in the general population. - To determine the mediation effect of lifestyle…
The main descriptive and analytic objectives are: Descriptive: To gather epidemiological evidence (prevalence, incidence) about the course of the mental, musculoskeletal and neurocognitive health (dependent variables) of…
The main objective of this study is to determine whether tubal flushing with oil-based contrast during HSG results into more pregnancies leading to live births when compared to tubal flushing with ExEm-foam during HyFoSy, and whether this approach…
The primary objective is to identify what causes colchicine resistance in FMF. Additionally, we will try to identify potential interventions to overcome resistance
To answer the following questions: 1. Who are the patients that need to be revaccinated?2. How many vaccinations are needed to restore SARS-CoV-2 immunity?3. Can the number of vaccinations needed to restore SARS-CoV-2 immunity be predicted?To…
The aim of this proof-of-concept study is to analyze the use of heart rate based variables using the Apple Watch:A) To predict Acute Chest Syndrome in patients hospitalized patients for painful crises;B) To predict painful crises in ambulant…
First, to establish the yield of the currently propagated pancreatic cyst surveillance program, and second, to identify possible alternative surveillance strategies, which might be more (cost) effective.
In this study we look at how long it takes for the levels of certain hormones and hormone-binding proteins to normalize discontinuation of COC use, in particular corticosteroid-binding globulin.
The aim of this study is to assess the position and alignment of the Atlas, as measured by the angles between the atlas and the surrounding vertebrae in healthy participants, patients with chronic headache, and patients with…
The primary objective of this study is to evaluate whether SAH patients at risk of developing DCI show a distinguished platelet RNA profile compared to patients without DCI. Secundary objective; to evaluate whether platelet RNA analyses can predict…
To develop a prediction model for BPD using a range of multimodal predictors assessed in the first two weeks of life.
Primary Objective: Primary: Gut microbiota (oral and fecal) and nasal microbiota composition in relation to autoimmunity status (antibodies (ANA, ANCA) and HLA subtype) and inflammatory functional assays as well as disease&…
The current study describes the Antisocial High-Risk Cohort (i.e., WP3, a sub-project) of the larger Growing Up Together in Society Project (see appendix A), which has the aim to predict and understand behaviour that negatively affects society:…
The primary objective is to evaluate longitudinal developmental changes in brain structure in patients aged 6-18 years with SCD. The secondary objective is to analyze the longitudinal relations between biomarkers, demographic characteristics, brain…