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Physical Exercise Training Programme COPD in Primary care

1) To assess the effectiveness of a physical exercise training programme in patients with mild to moderate COPD in the primary care setting, in comparison with usual care. 2) To analyse the main physiological (and behavioural) characteristics of…

The airway smooth muscle cell in asthma:
A genomics approach

To examine the difference in gene expression profiles of ASM in bronchial biopsy specimens between asthmatic patients, non-asthmatic allergic and non-asthmatic non-allergic controls.To associate the gene expression profiles with airway…

A PHASE 4, MULTINATIONAL, MULTICENTRE, DOUBLE BLIND, DOUBLE DUMMY, RANDOMIZED, PARALLEL GROUP, CONTROLLED CLINICAL STUDY OF FIXED COMBINATION BECLOMETHASONE DIPROPIONATE 100 µg PLUS FORMOTEROL FUMARATE 6 µg pMDI WITH HFA-134A PROPELLANT (CHF1535, FOSTER®) VERSUS FLUTICASONE 250 µg PLUS SALMETEROL 50 µg DPI (SERETIDE® DISKUS®) AS MAINTENANCE TREATMENT IN CONTROLLED ASTHMATIC PATIENTS

The objective of this study is to obtain information regarding the effectiveness and safety of a product called Foster® for the treatment of asthma. This product is a combination between two well known drugs: formoterol fumarate and beclomethasone…

A randomized clinical trial of surgery or radiosurgery (stereotactic radiotherapy) in patients with stage IA non-small cell lung cancer who are fit to undergo primary resection

To compare the outcomes of stereotactic radiotherapy (experimental arm) with that following primary surgery (standard arm) in a prospective phase III trial.

Reference value research for instantanious resistance and impulsoscillometrics

Goal of the researchTo investigate whether the newly measured parameters are deviating, these should be compared to the values of the healty volunteers. The goal to achieve is the determination of the healthy values as follows:- Determine reference…

Release of endogenous ligands of Toll-like receptors type 4 during mechanical ventilation in surgical patients with healthy lungs

Primary objective is to show the presence of endogenous ligands of TLR4 in the lung of patients being mechanically ventilated in a standardised way with clinical parameters. Secondary objective is to investigate the amount of endogenous ligands of…

A Double-Blind, Placebo-Controlled, Randomised, Parallel Group Phase IIa
Study to Evaluate the Histological Changes, Cellularity, Clinical Efficacy
and Safety of AZD1981 in Patients with Moderate to Severe Chronic
Obstructive Pulmonary Disease (COPD)

The aim of this study is to assess the effect of AZD1981 on histology (lung tissue biopsy) and inflammatory cells (broncho alveolar lavage [BAL] and induced sputum), symptoms, lung function, exercise tolerance and on inflammatory mediators in sputum…

The electronic nose in the discrimination of parent reported and doctor confirmed wheeze

We hypothesize that expiratory VOC-analysis by electronic nose is capable of:1. Discriminating between asymptomatic infants and infants with respiratory wheeze.2. Discriminating between parent-reported and doctors-confirmed wheezy infants.The aim of…

Systematic development and validation of an exacerbation risk index for COPD patients in general practice: tailoring treatment to an individual*s needs

The development of a practical COPD disease severity index developed and validated in primary care settings and thus ready-for-use in primary care after completion of the proposed project.

A randomized multi-center, double-blind, placebo-controlled, parallel-group trial to explore the effects of 78 week omalizumab treatment given as add on therapy on markers of airway inflammation and remodeling in patients with moderate to severe persistent allergic asthma receiving inhaled corticosteroids and long acting beta-agonists.

* Primary objective: To determine the effect of 78-weeks therapy with omalizumab compared to placebo on the number of sub-epithelial eosinophils, a marker of airway inflammation, in patients with persistent moderate to severe allergic asthma. *…

Uisng changes in pulmonary mechanics and gas exchange to better define the optimal pulmonary volume in patients ventilated for acute lung injury

Describe and observe *functional* recruitment as defined by the physiological responses (O2, dynamic compliance, CO2, haemodynamic responses), using these parameters to find the point of the most efficient alveolar minute ventilation at the lowest…

PIAMA (Prevention and Incidence of Asthma and Mite Allery) 11 year investigation

The aim of the extended follow-up of the PIAMA cohort is: To investigate changes during the ages of 8 to 11-12 years in lifestyle, nutrition, physical activity and health related attitude and behavior that are relevant to the development of asthma,…

Exposure assessment to quartz in construction workers with a elevated risk to silicosis

which particles can be found in induced sputum of construction workers? What is the composition, size and concentration of quartz particles measured in sputum of the different exposure groups?