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Gene expression during ciliagenesis: Towards a novel candidate gene list for Primary Ciliary Dyskinesia

We aim to assess gene expression patterns in cilia-producing cells from healthy controls to develop a candidate gene list for PCD.

A multi-center, prospective, blinded validation study to assess the accuracy of a host-response based diagnostics for distinguishing between bacterIal and viral etiology in pediatric patients with lower respiratory tract infections and fever without source

To externally validate the accuracy of a host-response based diagnostics for differentiating between bacterial and viral etiology in pediatric patients aged 2 to 60 months with LRTI or FWS.

A Prospective, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Safety and Efficacy of BAY 41-6551 as Adjunctive Therapy in Intubated and Mechanically-Ventilated Patients with Gram-Negative Pneumonia

To evaluate the efficacy (superiority) and safety of BAY 41-6551 as measured by the comparison of the clinical cure rate of aerosolized BAY 41-6551, administered via the PDDS Clinical, versus placebo (normal saline) at the Test-of-Cure (TOC0 visit…

Point-of-Care C-reactive protein to assist in primary care management of children with lower respiratory tract infection

Analyse costs and effects of point of care (POC) C-reactive protein (CRP) measurement in children with non-severe lower respiratory tract infection (LRTI) in primary care.

Preoperative inspiratory muscle training to prevent postoperative pneumonia in patients undergoing esophageal resection

Investigate if preoperative IMT affects the incidence of postoperative pneumonia after esophageal resection.

Reducing high respiratory drive to facilitate supported ventilation in ARDS patients: a pilot study

Primary Objective: to determine the feasibility of supported MV with low tidal volumes after partial neuromuscular blockade in patients with high respiratory drive. Secondary Objective: to determine the effect of partial neuromuscular blockade on…

A Phase 2, Randomized, Double-blind, Placebo-controlled, Efficacy and Safety Study of
Inhaled JNJ-49095397 (RV568) in Subjects With Moderate to Severe Chronic Obstructive
Pulmonary Disease

Primary ObjectiveThe primary objective is to assess the efficacy (as measured by change from baseline in prebronchodilator [preBD] percent predicted forced expiratory volume in one second [FEV1]) of JNJ-49095397 compared with placebo in subjects…

Targeting Antibiotics to Pseudomonas Aeruginosa in Small airways (TAPAS) study in patients with cystic fibrosis: pharmacokinetics (PK)

Primary objective: To determine the safety of once daily inhalation of the recommended daily dose of tobramycin with the Akita® and the PARI-LC® Plus nebulizer in patients with CF. Systemic absorption can be used as surrogate parameter for safety.…

Hypertonic saline in primary ciliary dyskinesia: a pilot study

We hypothesize that hypertonic saline nebulizations improve respiratory symptoms and quality of life in PCD patients.

The influence of the addition of rinsing with a 0.05% chlorhexidine-containing solution to usual daily oral hygiene care on the incidence of aspiration pneumonia in physically-impaired care home residents with dysphagia.

Primary objective: To assess the influence of the addition of rinsing with a 0.05% chlorhexidine-containing solution to usual daily oral hygiene care on the incidence of pneumonia in physically-impaired care home residents with dysphagia.Secondary…

Pharmacokinetic evaluation and tolerability of dry powder tobramycin by a novel device in patients with non cystic fibrosis bronchiectasis

The first objective to investigate is the pharmacokinetics of DP tobramycin using the Cyclops® at four different dosages. The other objective is the local tolerability of DP tobramycin using the Cyclops® at four different dosages.

Pharmacokinetics of nasally administered tobramycin and colistin in Cystic Fibrosis

To investigate the clinical pharmacokinetics of tobramycin and/or colistin after nasal administration. With this pharmacokinetic parameters the safety of this treatment can be investigated.

DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED STUDY TO EVALUATE THE SAFETY, TOLERABILITY AND PHARMACOKINETICS OF SINGLE ASCENDING DOSES AND THE EFFECT OF FOOD ON ORAL WCK 4873 IN HEALTHY ADULT VOLUNTEERS

To determine the safety and tolerability of single ascending doses of oral WCK 4873 in healthy subjects. To evaluate the pharmacokinetic (PK) profile of single ascending doses of oral WCK 4873 in healthy subjects.To evaluate the effects of food on…

Reduction of antibiotic therapy by biomarkers in patients with CAP episodes

2.1 Primary objective(s)The primary objective of this study is to determine whether a CRP guided and PCT guided treatment strategy (strategies mentioned below) can be used to safely and effectively reduce the duration of antibiotic treatment as…