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Mesenchymal stem cells in emphysema: finding the right niche for alveolar repair

The projects is divided in 3 aims: 1) To evaluate the regenerative capacity of lung-derived MSCs (LMSCs) from normal and emphysematous lung tissue and compare LMCSs to MSCs derived from other tissues2) To investigate the interaction of MSCs with the…

Bronchiolitis obliterans syndrome and other allo-reactive lung syndromes
after allogeinic hematopoietic stem cell transplantation
Is early prediction of bronchiolitis obliterans possible by using biomarkers possible?

In this study we would like to find new biomarkers in BOS after haematopoietic stem cell transplantation (HSCT), that may lead to earlier identification of BOS than a lung function decline.

Measuring work-of-breathing in mechanically ventilated children

The primary objective for this study is to compare the level and time course of the patient work-of-breathing during PS ventilation with the work-of-breathing during SIMV-PS ventilation with a lower rate of breaths per minute delivered by the…

myAirCoach * The use of home-monitoring and mHealth systems to predict asthma control and the occurrence of asthma exacerbations

Therefore, the aim of the myAirCoach project is to develop and evaluate technologies that assist patients with asthma. To this purpose we developed a one year observational quantification campaign in which we will identify potentially relevant self-…

A decision model for the management of acute exacerbation chronic obstructive pulmonary disease in the emergency department: flowchart for treatment allocation.

The primary objective is to validate a previously established prognostic instrument in the form of an algorithm (flowchart) in patients that present with AECOPD to the department of emergency medicine for classifying for out- or inpatient treatment…

Identifying optimal lung volume at lowest mean airway pressure during recruitment and weaning from paediatric high-frequency oscillatory ventilation

The primary objective is to assess the association between the EELV measured with RIP and EIT, and to graphically depict the changes in the pressure volume curve during stepwise decreasing the CDP in a recruited lung and correlate these with…

The effect of an outreaching care programme on the number of hospitalisation days and readmissions in patients hospitalized two times or more in the previous 12 months.

Reducing the number of readmissions in the revolving door patients diagnosed with COPD by means of an outreaching care nurse.

Low dose-CT for differentiation between AECOPD and pneumonia. An effective tool for diagnosis?

To determine the true prevalence of pneumonia in exacerbating COPD patients by low-dose CT

Optimizing lung imaging in people with Ataxia Telangiectasia applying improved MRI techniques.

The purpose of this research project is to improve the overall quality and resolution of the MRI images, to correct for movement effects during the procedure and to speed up the investigation. The goal is to enhance and standardize a technique…

Pilot study: Respiratory microbiome analysis by the IS-pro technology

Different sampling methods have been used for respiratory microbiome analyses, including both invasive as well as non-invasive techniques. We would like to investigate if the results of the bronchoscopy are comparable with results from the nose swab…

Implementing Treatment Algorithms for the Cure of Trauma Induced Coagulopathy (iTACTIC)

The primary objective is to compare the haemostatic effect of VHA-guided transfusion strategy versus optimized CCT guided transfusion strategy in haemorrhaging trauma patients. The secondary objectives of the study are to determine the effects of…

Effect of balloon volume on oesophageal pressure monitoring in critically ill children: a pilot study

To study the effects of varying amounts of air and patient position on oesophageal pressure measurements in children with and without lung injury.

Multi-arm, Non-randomized, Open-Label Phase IB Study to Evaluate GSK3052230 in Combination with Paclitaxel and Carboplatin, or Docetaxel or as Single Agent in Subjects with Solid Malignancies and Deregulated FGF Pathway Signaling (FGF117360)

Primary: to characterize the safety and tolerability of GSK3052230 in combination with chemotherapy regimens, to determine the MTD and to assess overall response rate in patients with stage IV or recurrent squamous NSCLC with FGFR1 gene…

Continuous monitoring of ventilation with the Hexoskin smart shirt to detect dynamic hyperinflation in COPD patients

The main objective of this study is to assess the ability of a wearable measurement system, the Hexoskin smart shirt, to detect and quantify dynamic hyperinflation. Secondary objectives are to determine the optimal measurement procedure and to…

Exhaled biomarker analysis for therapy stratification in asthma (STRATA)

1. Optimize breath collection settings for optimal use in children.2. Evaluate the use of breath biomarkers for the prediction of therapeutic response in asthmatic children.

Feasibility, reliability and relevance of quadriceps muscle endurance measurements in people with COPD

The primary objective is to investigate the measurement properties of isometric, isotonic and isokinetic protocol to assess quadriceps muscle endurance in patients with COPD. Our secondary objective is to determine the relationship between…

A Multi-center, Prospective, Randomized, Controlled Trial of Endobronchial Valve (EBV)
Therapy vs. Standard of Care (SoC) in Heterogeneous Emphysema.

To compare the clinical outcomes of Endoscopic Lung Volume Reduction (ELVR) using the Pulmonx Zephyr Endobronchial Valve (EBV) vs. Standard of Care (SoC) in the treatment of heterogeneous emphysema subject in a controlled trial design setting.

PRotective VENTilation in Patients not Fulfilling the Consensus Definition for Moderate or Severe ARDS at Start of Ventilation * PReVENT, a Randomized Controlled Trial

The present study aims at comparing a ventilation strategy with a lower tidal volume and a higher respiratory rate with ventilation using a higher tidal volume and a lower respiratory rate in ICU patients without moderate or severe ARDS.

Use of lung mechanics to identify the optimal level of positive end-expiratory pressure in mechanically ventilated children with acute lung injury: a pilot study

The primary objective is to study the level and time course of the end-expiratory lung volume during the individual incremental * decremental PEEP titration; the secondary objective is to study if there is a significant association between the end-…

Identifying REsponders and exploring mechanisms of ACTION of the endobronchial coil treatment for emphysema

The objectives of the study are to gain more knowledge on 1) the effect of the LVRC treatment on patient-based outcomes like physical activity, 2) the underlying physiological mechanism of the treatment, and 3) the predictors of response to the…