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Diarrhea during use of the oral angiogenesis inhibitors sunitinib and sorafenib

To identify what might be the cause of the occurrence of diarrhea during the use of angiogenesis inhibitors sunitinib and sorafenib in patients with a malignancy.

OPEN LABEL EUROPEAN STUDY TO SUPPORT THE EARLY IDENTIFICATION OF PATIENTS WITH CHRONIC NEUROPATHIC LOW BACK PAIN IN PRIMARY CARE AND TO ASSESS THE EFFECTIVENESS AND TOLERABILITY OF PREGABALIN IN THIS POPULATION.

Primary Objectives1. To raise awareness and enhance the diagnosis of patients with chronic low back pain (CLBP) with a neuropathic pain component who are refractory to standard analgesic therapy and/or one treatment for neuropathic pain in a primary…

Pilot study: Is concomitant administration of lidocaine during oxaliplatin infusion able to prevent pain as a result of oxaliplatin induced acute neuropathy?

Primary objectiveTo evaluate the efficacy of low dose intravenously lidocaine in comparison with placebo in terms of pain relief after the first oxaliplatin administration measured by a numeric rating scale (NRS 0-10).Secondary objectives1.…

Putting resistance under the microscope

Main objectiveLorazepam is frequently used as an anaesthesiological premedication before surgery in order to reduce patients resistance. Does lorazepam also improve the quality of recovery in patients scheduled for day-case-surgery?Secondary…

Evaluation of cognitive function of patients treated with sunitinib or sorafenib (UMCONCO200904

Tot evaluate the cognitive function of patients treated with sunitinib or sorafenib for metastatic renal cell cancer or a GIST, in order to get more insight in the prevalence, typeand etiology of cognitive dysfunctioning during treatment with…

Study on the influence of sunitinib and sorafenib on cognitive functioning a cross sectional study (UMCNONCO200901)

To assess the influence of sunitinib and sorafenib on subjective and objective cognitive functioning in patients with metastatic renal cell cancer or a GIST, in order to get more insight in the prevalence, type and etiology of cognitive…

The influence of dropsize of tropicamide 0.5% eyedrops on pupildilation

Primary:Is the degree of pupildilation, achieved after administrating a 4.5 microliter microdrop tropicamide 0.5% equivalent to the pupildilation after a regular 30 microliter eydrop tropicamide 0.5% in healthy volunteers?Secondary: Is there a…

het optimaliseren van de voorbereiding voor sigmoidoscopie in de regio; Moviprep versus Bisacodyl/klysma, een enkelblind gerandomiseerd onderzoek

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Combined effects of SGLT2 inhibition and GLP-1 receptor agonism on food intake, body weight and central satiety and reward circuits in obese T2DM patients

Primary objective:To investigate the separate and combined actions of the SGLT2 inhibitor dapagliflozin and GLP-1 receptor agonist exenatide on activity in central reward and satiety circuits in response to food related stimuli in obese patients…

Fresh Intravenous Blood Samples for TBI Diagnostic Assay Development with Philips Point of Care System (FIRST DOWN)*

The purpose of this study is to collect fresh whole blood from subjects who have had a suspected head injury (Glasgow Coma Scale score 9-15), for use during the early phase of development of an investigational diagnostic assay platform (Philips…

Randomized controlled trial: Comparing a low volume sulfate regimen without bisacodyl, to a polyethylene glycol regimen with bisacodyl at colon preparation for colonoscopy

We hypothesized that bowel preparation will be comparable between groups as measured using the Boston Bowel Preparation Scale and that the adenoma detection rate will be comparable across groups. Furthermore, we hypothesized that patient experience…