44 results
In this proposed study, we aim to test not only the safety and biodistribution of [68Ga]Sarabesin 3, but also its potential to visualise prostate cancer. If the peptide proves to be successful, a next study will be initiated to test the potential to…
Primary objectiveTo determine whether adding the MRI/US fusion technique using mpMRI images for directed biopsy of a ROI leads to a higher detection rate of PCa per patient compared to a systematic 12-core biopsy protocol including directed biopsy…
The overall goal of this study is to further validate and improve the sentinel node procedure for prostate cancer using ICG-99mTc-nanocolloid. The first objective aims at further validation of the sentinel node procedure for prostate cancer via…
Our primary objective is to develop an easily assayable germline-based panel of biomarkers to aid in selecting prostate cancer patients for management with active surveillance. As a secondary objective, we tend to incorporate potentially promising…
Primary Objective:To assess the ability of BR55 to identify area(s) of VEGFR2 expression in human prostate by ultrasound molecular imaging on the basis of a visual score in comparison with histopathology analysis (location based on expression of…
The primary aim of this pilot study is to determine whether CTCs are a reliable predictor of survival in men with CRPC receiving docetaxel-based chemotherapy by using the Veridex CellSearch system and the biomarkers PCA3, TMPRSS2-ERG and biomarker…
The primary objective of this study is to compare HistoScanningTM guided prostate biopsy with systematic biopsy in the detection of prostate cancer in men candidate for a first or second biopsy procedure.
Primary ObjectiveTo establish a prospective cohort of patients undergoing radiotherapy for breast, prostate or lung cancers following local regimens and collecting standardised radiotherapy toxicity data, non genetic risk factor data and samples for…
To validate two novel genomic biomarkers that provide information with respect to the presence of PCa, disease aggressiveness, and progression towards recurrent and metastatic disease.
Primary Objective: To assess the detection rate of 18 F-FDHT PET/CT in men with recurrent prostate cancer after radiotherapy who are candidates for local salvage treatment.Secondary Objective(s): To assess the detection rate and accuracy of 18 F-…
The primary objective is to determine the optimal pharmacokinetic model of 68Ga-PSMA PET/CT, so 68Ga-PSMA PET/CT results can be quantified in prostate cancer.The secondary objectives are to determine whether the optimal kinetic model of 68Ga-PSMA…
The purpose of our study is to prospectively establish in vivo in patients proof of principle for the RUNMC MR imaging-compatible robotic system designed for image-guided prostatic needle intervention.
The primary objective is to determine if the incorporation of Multimodality MRI including MRGB within the Prostate cancer Research International for Active Surveillance (PRIAS) study for low-risk low volume prostate cancer leads to a higher number…
The potential use of intraoperative, ICG based sentinel node identification, fluorescence imaging of LN*s during lymphadenectomy for prostate cancer
To apply a novel blood assay to 150 patients undergoing a radical prostatectomy in order to assess whether this test can accurately identify indolent cancers and thereby prevent unnecessary treatments. To increase the accuracy of the flow cytometric…
The primary objective is to compare the sensitivity and specificity of tumour size and growth assessed with HistoScanningTM with the PRIAS parameters (PSA changes). The sensitivity and specificity of both methods will be measured with adverse biopsy…
To determine the diagnostic accuracy of multimodality MRI in detecting locally recurrent prostate cancer two years after treatment with external beam radiation therapy.
Our goals are to collect blood from men randomized to the intervention arm of the Dutch part of the European Randomised study of Screening for Prostate Cancer (ERSPC) and actually screened (www.erspc.org, N=19.970, METC 138.741/1994/152). With the…
Primary Objective: the primary objective of this study is to determine the feasibility of [18F]FDHT PET/CT for in vivo evaluation of bone metastases in prostate cancer. Active locations will be compared with those seen on conventional imaging (bone…
To investigate the additional value of MRI and MRI-guided biopsy in men with an elevated PSA in the general practitioners* (GP) practice regarding the detection of both insignificant and significant cancer, and reduced biopsies.