47 results
In subjects with T2DM, with inadequate glycemic control, who have a history or high risk of CV disease:Primary Objectives*to assess the effect of canagliflozin plus standard of care relative to placebo plus standard of care on CV risk as measured by…
To assess the efficacy of a TCC, a BTCC and a cast shoe with similar plantar soles on offloading the previous ulcer location in people with DM and peripheral neuropathy.
Primary objectiveIn subjects with T2DM receiving standard of care but with inadequate glycemic control and at elevatedrisk of cardiovascular (CV) events to assess the effect of canagliflozin compared to placebo onprogression of albuminuria.Secondary…
ObjectivesPrimary objectiveThe primary objective is to determine the effect of dapagliflozin relative to placebo oncardiovascular outcomes when added to current background therapy in patients with type 2diabetes mellitus (T2DM) with either…
To assess the cost-effectiveness and cost-utility of at-home foot temperature monitoring to reduce incidence of foot ulcer recurrence in patients with diabetes. Main research questions:1. What is the cost-effectiveness of enhanced therapy in…
We will identify factors that interfere with the beneficial effects of exercise on the vasculature in T2DM.
The main objectives of this monitoring study are: To asses 1) the number of potential participants, selected by the health care professionals, that are actually included in the Beweegkuur; 2) the number of participants that follow the complete…
Controlling the glycemic impact of food products may reduce glycemic and insulinemic responses. This may result in a decreased inhibition of fat oxidation rate and lower plasma TAG concentration. A higher postprandial fat oxidation may result in…
The first objective is to examine the impact of 4-month walking training on physical fitness, insulin resistance and cardiovascular risks in T2DM and their controls and to assess whether these effects are preserved 3 months after cessation of the…
To assess whether dietary nitrate supplementation blunts the ischemia-reperfusion-induced rise in cTnT levels following exercise in type 2 diabetic patients.
1) To investigate the impact of keeping/loosing diabetes on quality of life and psychological well-being in a group of (morbidly) obese patients who underwent bariatric surgery, and 2) To explore whether we can predict postoperative quality of life…
The aim of the study is to evaluate the efficacy of sensor augmented pump (SAP) therapy with MiniMed* 640G and SmartGuard* in preventing hypoglycemic events in comparison with continuous subcutaneous insulin infusion (CSII) therapy in type 1…
The main objective is to assess the impact of the P4 approach on established markers of glucose metabolism. Secondary objectives are changes in physical characteristics, questionnaires and the indices for beta cell function, hepatic insulin…
To disclose the pathofysiologic basis of the favourable risk profile by measuring factors associated with cardiovascular disease.
To evaluate if the program *Run2gether* can change physical behavior in children with obesity and/or diabetes, and thereby increase physical fitness level and insulin sensitivity en reduce body weight. An additional goal for children with diabetes,…
The aim of this randomised, parallel study in patients with DMT2 is to investigate if the added use of skin autofluorescence to the UKPDS risk score will lead to changes in systolic blood pressure and medical treatment (primary measures of effect)…
The aim of this study is to evaluate the effect of the intervention *Powerful Together against Diabetes* on metabolic control, health related outcome measures, diabetes related behaviour, psycho-social outcome measures and intermediate outcome…
To evaluate the accuracy of trained hypo-alert dogs and to evaluate the quality of life of patients with such a dog.
The objective of this study is to compare the effects of noise with different characteristics on balance in patients with diabetic neuropathy
To establish efficacy of pre-travel vaccinations by determination of protective serum antibody titres against hepatitis A, DTP and polysaccharide Vi of Salmonella typhi. To quantify health risks related to preventive actions and consequences of…