95 results
Research Questions: Primary:1. Does a single night of short sleep reduce metabolic flexibility following a mixed meal challenge?2. Does a single night of short sleep alter the responsiveness of the HPA-axis?3. Are the disturbances of a single night…
Primary objective of this study is to assess changes in brain connectivity and activity in the Default Mode and Salience Network (hypothalamus, prefrontal cortex, nucleus accumbens, Ventral Tegmental Area) after different sugars and sweeteners.
There are two objectives for this study: first, to find specific serum beta cell damage markers that can serve as a clinical predictive tool for beta cell allograft loss. Second, to compare quality of life and diabetes-related outcomes in patients…
This research project aims to determine the feasibility of setting up a randomized controlled trial to study the effects of different fluid management protocols on the outcome of mechanically ventilated pediatric patients with acute infectious lung…
- To determine whether there is a mitigated immediate immune response to islet infusion in immunosuppressed recipients- To determine if complement activation during immediate immune response is affected in immunocompromised recipients
To confirm the effect of continious subcutaneous insulin infusion (CSII treatment) with faster-acting insulin aspart in terms of glycaemic control by comparing it to CSII treatment with NovoRapid®, in adults with Type 1 diabetes Mellitus, using a…
Verification of functional tests with the LoRRca, a next generation ektacytometer, on red blood cells of healthy individuals with or without comorbidities/risk factors.
The primary objective of this study is to investigate the effect of different levels of oral phenylalanine supplementation on the blood concentration and diurnal variation of phenylalanine and tyrosine in HT1 patients treated with NTBC. This in…
To assess in paediatric patients with ASD with and without (first-time) antipsychotic medication• the prevalence and incidence of insulin resistance and other metabolic abnormalities• the risk factors for insulin resistance and other metabolic…
We will investigate the effect of the combination of moderate physical activity and a standard meal on the onset of low grade intestinal ischemia. Will will use the serological biomarker I-FABP to determine the occurrence of low grade intestinal…
Aims of the Study: Our main aim is to characterize cortical brain plasticity in individuals with impaired fasting glucose (IFG) and patients with type II diabetes mellitus (DM2) as compared with age-, gender-, and IQ-matched healthy controls(HC).•…
Objective with respect to patient care: Obese patients have an increased risk of developing heart failure. By gaining insight on the role of obesity in cardiac dysfunction it will be possible to provide a better risk stratification for the onset of…
to investigate the effect of 5 weeks dapagliflozin 1dd 10mg treatment on glucose and cholesterol fluxes in patients with type 2 diabetes on stable rosuvastatin treatment.
To demonstrate non-inferiority of Toujeo versus *standard of care* basal insulin therapy asmeasured by HbA1c change from baseline to Month 6.
A trial investigating the cardiovascular safety of oral semaglutide in subjects with type 2 diabetes
The primary objective is to confirm that treatment with oral semaglutide does not result in an unacceptable increase in cardiovascular risk compared to placebo (rule out 80% excess risk) in subjects with T2D at high risk of cardiovascular events.The…
Based on the gaps in our knowledge (as stated above), we have formulated the following objectives:- To quantify the degree of hepatic fat accumulation and fibrosis in patients with HFI. - To gain more insight in the mechanism leading to NAFLD in…
To investigate whether postprandial bacterial translocation and the subsequent inflammatory response can be modulated by oral vancomycin in lean versus obese subjects. Moreover, we will study the role of platelets in postprandial inflammation.
(Primary) Determine whether measuring the expression level is a good functional test for confirming the genetic diagnosis in IRIDA by establishing the relation between the TMPRSS6 mRNA expression and the phenotype in IRIDA patients and their family…
To study feasibility, reliability and validity of a specific set of outcome measures in children with mitochondrial myopathy.
Objectives of the study are:1. To evaluate the safety and tolerability of ascending single doses of KBP-089 in healthy male subjects;2. To evaluate the pharmacokinetics of ascending single doses of KBP-089 in healthy male subjects;3. To assess the…