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MRI verified accuracy of intracompartmental pressure measurement in the deep posterior compartment of the lower leg: a pilot study

To analyse the accuracy of the positioning of the catheter that is used for pressure measurement deep flexor muscles of the lower leg using magnetic resonance imaging (MRI).

ROBot-aided system Identification: a novel tool for diagnosis and assessment in Neurological rehabilitation: *ROBIN*

Primary objective of this study is to assess the reliability, validity, and diagnostic value of the neuromechanical parameters of joint impedance estimated by nonlinear SIPE technology in patients with a spastic paresis.

A phase IIb, open-label study to assess the efficacy, safety, pharmacodynamics and pharmacokinetics of multiple subcutaneous doses of BMN 045 (previously known as PRO045) in subjects with Duchenne muscular dystrophy

Primary objective:To assess the efficacy of BMN 045 after 48 weeks treatment in ambulant subjects with Duchenne muscular dystrophy.Secondary objectives:To assess the safety and tolerability of BMN 045 after 48 weeks of treatment in all study…

The effect of Neuromuscular Electrical Stimulation on post-prandial muscle protein accretion in healthy elderly men

The aim of this study is to investigate the effect of a single bout of NMES on muscle protein synthesis rates in healthy elderly males.

Muscle relaxation time as outcome measure in patients with non-dystrophic and dystrophic myotonic syndromes; voluntary handgrip- versus peripheral nerve stimulation myometry

In this study we want to investigate if the muscle-relaxation time (muscle-RT), calculated from force profiles obtained with two different experimental methods (1) voluntary handgrip- and (2) peripheral nerve stimulation myometry, is a reliable and…

Exercise testing in ambulatory pediatric patients with Duchenne Muscular Dystrophy and Becker Muscular Dystrophy: a pilot study

The purpose of this study is to examine the feasibility of both the CPET and the 6MWT as outcome measures for exercise capacity in children with DMD and BMD. This study will focus on ambulatory children with DMD and BMD. These patients frequently…

Abduction brace versus sling after arthroscopic cuff repair

Primary Objective: Is there reduction in pain using an abduction brace in patients undergoing arthroscopic cuff repair? Secondary Objectives: - Are there differences in function and recovery of the cuff, determined using questionnaires and echo?- Is…

A Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Subcutaneous Injection of ABT-110 in Healthy Volunteers and Subjects with Chronic Low Back Pain

T\o evaluate the pharmacokinetics, safety and tolerability of the research medication

Assessment of asymmetrical innervation of the right and left m. puborectalis as a possible cause of idiopathic incontinence, by using concentric needle electrodes in an electromyography investigation of the pelvic floor muscles.

Is it possible to make a discrimination in muscle activity between the right and left puborectalis muscle by using concentric needle electrodes in an electromyography investigation of the pelvic floor muscles?When a asymmetry is found, what can be…

Incidence of pelvic floor injury after a first normal vaginal delivery in women with and without a mediolateral episiotomy (EPILEVA study)

Primary ObjectiveDifference in incidence of an avulsion injury and morphological changes of the levator ani muscle after a first normal vaginal delivery between participants with and without a mediolateral episiotomy.Secondary ObjectiveChanges in…

Arm training in boys with Duchenne Muscular Dystrophy

To determine whether 3D arm training with arm-support is effective in delaying the loss of arm functions in daily activities from an early age onwards in boys with DMD.

Fasciotomy as treatment of Chronic exertional compartment syndrome of the deep posterior compartment - a prospective study

This study aimes to investigate wheter or not a fasciotomy of the deep posterior compartment of the lower leg leads to a lowering of the intracompartimental pressure, an objective parameter. . This study will also investigate wheter or not a…

Post-exercise recovery after dietary protein ingestion in healthy young men

To determine whether the intake of minced beef is equally effective as ingestion of a bovine milk protein beverage in stimulating post resistance exercise muscle protein synthesis rates in young men.

The impact of dietary protein supplementation and age on muscle mass loss during short term one-legged knee immobilization

To investigate whether elderly individuals lose muscle mass at a greater rate than young individuals during 5 days of one legged knee immobilization, and whether dietary protein supplementation can alleviate such muscle loss in the elderly.

'Evaluation of respiratory muscle function after posterior scoliosis surgery, using dynamic MRI and exercise tests'

I. To evaluate what the impact is of posterior scoliosis correction on respiratory muscle function (strength, endurance, power and work of breathing).II. To evaluate the relation of changes in respiratory muscle function, due to the posterior…

Measurement of upper extremity function in persons with neuromuscular diseases (NMD)

Obtain information regarding the movement abilities and muscle strength in persons with several neuromuscular diseases, which can be used to develop a motion controlles arm suport for daily use and training of arm function.

Cross cultural validation of the Child Activity Limitations Interview (CALI), Bath Adolescent Pain Questionnaire (BAPQ) and Fear of Pain questionnaire (FOPQ) for adolescents with chronic pain.

To investigate the cross-cultural validity of the Dutch version of the following questionnaires that identify the adolescent*s level of functioning with chronic pain:1. Child Activity Limitations Interview (CALI) 2. Bath Adolescent Pain…

The effects of daily neuromuscular electrical stimulation during short term one-legged knee immobilization on muscle mass in healthy young men

To investigate the effects of 5 days of one legged knee immobilization with or without daily NMES on quadriceps CSA, lean mass and muscle fiber characteristics.

Validation of estimated motor unit properties as obtained by inverse modelling of motor unit templates using high-density surface EMG

To validate and determine the accuracy of an inverse model for determining motor unit properties based on high-density surface EMG measurements from biceps brachii and tibialis anterior muscles.

Skeletal Muscle Metabolism during Rest, Exercise and Recovery in Patients with VLCADD and healthy controls

To investigate whether patients with VLCADD have a different energy metabolism compared to healthy controls.