130 results
Main Objective:To evaluate the long-term safety and tolerability of BYM338 in the treatment of sIBM and to further evaluate the effect of three BYM338dose regimens against placebo in increasing the distance traveled as measured by the 6 Minute…
The primary objective is to determine the effect of dietary ribose supplementation on muscle function in patients with isolated LGMD as caused by a dystroglycanopathy. The secondary aim is to determine if ribose is well tolerated in this patient…
This is a post-marketing study to further assess the safety and efficacy of the InSpace* device implantation in comparison to surgical repair of full thickness MRCT . The efficacy will be assessed by comparing the pre- and post- operative shoulder…
The objective of the study is to assess the safety, tolerability and efficacy of PRO044.
The objective of this feasibility study is compare the smart AFO + standardized shoes to subjects* own AFO + own shoes. Subjects* experiences with the orthotic devices will be evaluated and points for improvement will be asked. Subjects* performance…
Overall Objective: To define the properties of whey, casein, milk protein, as well as soy protein with and without additional leucine to augment post-exercise muscle protein synthesis when co-ingested with a carbohydrate containing recovery drink.…
Primary Objectives: To investigate whether differences exist in the mitochondrial energy generating capacity of skeletal muscle of statin users with SAMS compared to statin users without SAMS and controls (non-statin users).Secondary objectives:2A.…
(1) To phenotype fibromyalgia patients in terms of endogenous modulation of pain, central sensitization/facilitation, the presence of a neuropathic pain component and small fiber neuropathy;(2) To assess the effect of a three-month treatment with…
From p12 of C1 protocol document:To assess how diurnal rates of muscle protein synthesis are altered during a short-term (3-day) implementation of resistance exercise training when compared to normal daily activity.
This study is not intended to improve your health, but is necessary for the further development of RO7034067 .The study will be performed in 3 parts, Parts 1, 2 and 3. This document only refers to Part 1/2/3 of the study . Part 1:A single dose will…
This aim of this study is to evaluate the secondary outcome measures including three to four year re-injury data.
To define a dose-response relationship after intrinsically labeled milk protein ingestion on myofibrillar and mitochondrial muscle protein synthesis after a single bout of endurance exercise.
Primary: to demonstrate that at least one dose regimen of BYM338 in sporadic inclusion body myositis patients will increase the distance traveled as measured by change from baseline at Week 52 of the 6 minute walking distance test relative to…
In this phase I/II clinical study will assess the safety, effectiveness and homing of asCTMP, namely autologous mesoangioblasts, that will be injected 3x intra-arterially in right lower leg via catheter in 5 indivuals that carry the m.3243A>G…
This study aims to investigate the impact of a newly developed oral nutritional supplementation (ONS_01) primary on body weight and lean body mass and secondary on physical performance, muscle health and immune function in malnourished elderly…
This study examines the feasibility and an indication of possible effects of ZORA robot based intervention on play in rehabilitation and special education for children with severe physical disabilities.
(voor meer details zie CMO-protocol paragraaf 2: Objectives) Primary Objective: The objective of this project is to further refine N-of-1 trial methodology, and explore whether Bayesian analysis of multiple N-of-1 trials can serve as a sufficient…
To investigate the relationship between self-reported disability, performance based disability and psychological factors in patients with complaints of whiplash.
The primary objective of this project is to contribute to the knowledge of the optimal medical care of DMD patients with regard to the optimal level of physical activity by examining the effects of training primarily upon muscle endurance and/or the…
The purpose of the study is to investigate whether a protein pulse feeding pattern increases the appearance of labeled phenylalanine in skeletal muscle tissue over a 24 h period in the elderly.