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A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER STUDY OF THE SAFETY AND EFFICACY OF 3-MONTH SUBCUTANEOUS REGN1033 TREATMENT IN PATIENTS WITH SARCOPENIA

Please refer to protocol, section 1.2 "Rationale"

A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial of Tadalafil for Duchenne Muscular Dystrophy

The primary objective is to test the hypothesis that once daily tadalafil administered orally for 48 weeks lessens the decline in ambulatory ability as measured by the 6MWD compared to placebo in boys with Duchenne muscular dystrophy (DMD). Two…

Intra-subject variability in pain scoring and the consequences for analgesia treatment

In the current study we want to further explore the predictability of pre-treatment pain variability on the probability to experience pain relief. Knowledge on the understanding of individual differences in analgesic properties of a drug is of…

Effect of Fecal Transplantation on Satiety, Sarcopenia, Inflammation and Chemotherapy Toxicity in patients with Metastasized Oesophageal and Gastric Cancer.

Primary objective:Effect of fecal transplantation (from healthy obese donors) on faecel microbiota composition in relation to satiety (questionnaires, biomarkers) and metabolism (REE ) in patients with metastasized or locally advanced oesophageal or…

A Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging, Dose-Loading Study to Evaluate the Efficacy, Safety, and Tolerability of JNJ-42160443 as Adjunctive Therapy in Subjects With Inadequately Controlled, Moderate to Severe, Chronic Low Back Pain

Primary ObjectivesThe primary objectives of this study are to evaluate the analgesic effect size over 12 weeks of several doses and dosage regimens of JNJ-42160443 compared with placebo in subjects with moderate to severe, chronic, low back pain (…

Extension of the CBYM338B2203 phase IIb/III study to evaluate the long-term efficacy, safety and tolerability of intravenous BYM338 in patients with sporadic inclusion body myositis

Main Objective:To evaluate the long-term safety and tolerability of BYM338 in the treatment of sIBM and to further evaluate the effect of three BYM338dose regimens against placebo in increasing the distance traveled as measured by the 6 Minute…

The effects of protein type and added leucine on post-exercise muscle protein synthesis

Overall Objective: To define the properties of whey, casein, milk protein, as well as soy protein with and without additional leucine to augment post-exercise muscle protein synthesis when co-ingested with a carbohydrate containing recovery drink.…

A randomized, double blind, placebo-controlled study on the effect of 3 months treatment with the analgesic tapentadol on conditioned pain modulation (CPM) and pain relief in patients with chronic pain from fibromyalgia

(1) To phenotype fibromyalgia patients in terms of endogenous modulation of pain, central sensitization/facilitation, the presence of a neuropathic pain component and small fiber neuropathy;(2) To assess the effect of a three-month treatment with…

A SINGLE-CENTER, RANDOMIZED, INVESTIGATOR/SUBJECT-BLIND, ADAPTIVE SINGLE-ASCENDING-DOSE (SAD), PLACEBO-CONTROLLED, PARALLEL STUDY TO INVESTIGATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS (INCLUDING THE EFFECT OF FOOD AND THE EFFECT OF ITRACONAZOLE ON THE PHARMACOKINETICS OF A SINGLE ORAL DOSE OF RO7034067), AND PHARMACODYNAMICS OF RO7034067 FOLLOWING ORAL ADMINISTRATION IN HEALTHY SUBJECTS

This study is not intended to improve your health, but is necessary for the further development of RO7034067 .The study will be performed in 3 parts, Parts 1, 2 and 3. This document only refers to Part 1/2/3 of the study . Part 1:A single dose will…

The effects of protein dose response on myofibrillar and mitochondrial protein synthesis after endurance exercise in young men.

To define a dose-response relationship after intrinsically labeled milk protein ingestion on myofibrillar and mitochondrial muscle protein synthesis after a single bout of endurance exercise.

A randomized, double-blind, placebo-controlled, multicenter, parallel group, dose-finding, pivotal, phase IIb/III study to evaluate the efficacy, safety and tolerability of intravenous BYM338 at 52 weeks on physical function, muscle strength, and mobility and additional long-term safety up to 2 years in patients with sporadic inclusion body myositis (CBYM338B2203)

Primary: to demonstrate that at least one dose regimen of BYM338 in sporadic inclusion body myositis patients will increase the distance traveled as measured by change from baseline at Week 52 of the 6 minute walking distance test relative to…

Combining N-of-1 trials to estimate population clinical effectiveness of drugs using Bayesian hierarchical modeling. The case of Mexilitin for patients with Non-Dystrophic Myotonia.

(voor meer details zie CMO-protocol paragraaf 2: Objectives) Primary Objective: The objective of this project is to further refine N-of-1 trial methodology, and explore whether Bayesian analysis of multiple N-of-1 trials can serve as a sufficient…

Vitamin D suppletion and aspecific musculo-skeletal disorders

To investigate the effect of suppletion of vitamin D on aspecific musculo-skeletal disorders

A randomized, double blind, placebo controlled, multi-centre study to assess the pharmacodynamics, pharmacokinetics, safety and tolerability of BYM338 in chronic obstructive pulmonary disease patients with cachexia (CBYM338X2204)

Primary: Assess the effect of i.v. infusions of BYM338 on muscle volume of the thigh (assessed by MRI) at 4, 8, 16 and 24 weeks, compared to placebo, in COPD patients with pulmonary cachexia.Secondary: Effect on 6-minute walk test, safety and…

Autologous conditioned plasma injection for acute hamstring muscle injury.

In this study two treatment groups will be compared: ACP injection in combination with exercise therapy and placebo injection in combination with exercise therapy.

Protect, The impact of a high protein diet on the preservation of muscle mass during caloric restriction in overweight middle-aged to elderly people

To investigate the effects of a high protein diet vs. standard protein diet for 12 weeks on preservation of muscle mass during caloric restriction in overweight and obese middle-aged to elderly people.

Effects of levosimendan on diaphragm function in mechanically ventilated patients

To determine the effect of levosimendan on diaphragm function in mechanically ventilated patients.

The impact of the macronutrient composition of a nutritional supplement on postprandial skeletal muscle protein synthesis in elderly

Obtain more insight in the preferred macronutrient composition of an oral nutritional supplement.

Inspiratory muscle training prior to peripheral muscle training in patients adolescents with Cystic Fibrosis.

1. Is a home-based peripheral muscle training program (5BX) more effective in (a) increasing peak work rate and (b) patients* preferred occupational performance in patients with CF who are preconditioned by IMT?2. Which variables are indicators of…

A study to evaluate the sensitivity of muscle velocity recovery cycles to determine changes in muscle excitability, by evaluating pharmacological effects in healthy subjects, and by comparing healthy subjects with myasthenia gravis patients

Primary ObjectivesPart A- To evaluate the sensitivity of muscle velocity recovery cycles (MVRCs) to determine effects of ischemia on muscle membrane potentials- To evaluate the sensitivity of MVRCs to determine effects of mexiletine on muscle…