68 results
The primary objective of this study is to compare respiratory muscle strength values obtained using volitional techniques with values obtained using non-volitional techniques. The secondary objective is to compare the change for these two sets of…
Primary objective: To assess the efficacy of BMN 053 at recommended dosing regimen after 48 weeks treatment in ambulant subjects with Duchenne muscular dystrophy.Secondary objectives: - To assess the safety and tolerability of BMN 053 after single…
Primary objective:To assess the efficacy of BMN 045 after 48 weeks treatment in ambulant subjects with Duchenne muscular dystrophy.Secondary objectives:To assess the safety and tolerability of BMN 045 after 48 weeks of treatment in all study…
The aim of this study is to conduct a pilot study of weight-supported ambulation training in ICU patients and to assess its feasibility of the use in daily practice, and to obtain information for the development of a randomized clinical trial for…
The purpose of this study is to assess the safety, tolerability and efficacy of long term drisapersen in subjects with DMD.
Main objective: The main objective of this open-label, single arm study is to further characterize the safety, tolerability and effectiveness profile of olesoxime in SMAThe primary safety objective for this study is as follows:To evaluate the safety…
Looking into the effects of raw vs boiled eggs vs isocaloric low-protein meal on muscle growth.
The objective of this prospective study is to answer the question: "Leads isolated dynamic resistance training of the lumbal extensor muscles to decreased multifidus atrophy and will MRI show an increasing multifidus cross sectional area and…
The objective of this pilot study is to demonstrate that NAVA ventilation is superior compared to pressure support and pressure control ventilation in work of breathing (expressed as pressure-time product) patient ventilator synchrony and other…
Primary Objective: Is there reduction in pain using an abduction brace in patients undergoing arthroscopic cuff repair? Secondary Objectives: - Are there differences in function and recovery of the cuff, determined using questionnaires and echo?- Is…
T\o evaluate the pharmacokinetics, safety and tolerability of the research medication
The Sport-2-Stay-Fit (S2SF) Study will investigate if an after school sports program increase the sustainability of a standardized interval training program in children and adolescents with a physical disability or chronic disease.
This study aims to examine the feasibility and an indication of possible effects of an IROMEC robot based play therapy within rehabilitation and special education on the level of playfulness of children with severe physical disabilities.
The primary objective is to determine the effect of dietary ribose supplementation on muscle function in patients with isolated LGMD as caused by a dystroglycanopathy. The secondary aim is to determine if ribose is well tolerated in this patient…
The objective of the study is to assess the safety, tolerability and efficacy of PRO044.
The objective of this feasibility study is compare the smart AFO + standardized shoes to subjects* own AFO + own shoes. Subjects* experiences with the orthotic devices will be evaluated and points for improvement will be asked. Subjects* performance…
Primary Objectives: To investigate whether differences exist in the mitochondrial energy generating capacity of skeletal muscle of statin users with SAMS compared to statin users without SAMS and controls (non-statin users).Secondary objectives:2A.…
From p12 of C1 protocol document:To assess how diurnal rates of muscle protein synthesis are altered during a short-term (3-day) implementation of resistance exercise training when compared to normal daily activity.
In this phase I/II clinical study will assess the safety, effectiveness and homing of asCTMP, namely autologous mesoangioblasts, that will be injected 3x intra-arterially in right lower leg via catheter in 5 indivuals that carry the m.3243A>G…
This study aims to investigate the impact of a newly developed oral nutritional supplementation (ONS_01) primary on body weight and lean body mass and secondary on physical performance, muscle health and immune function in malnourished elderly…