38 results
Primary Objectives:• show effectiveness of the SMSC instrument in 3D correction of the spine prior to placement of the implants.The hypothesis is that to achieve de-rotation of the spine without failure of the pedicle screws, de-rotation has to be…
Documentation of the patients' functional recovery and quantification of fusion after implantation of 3-D trabecular titanium cages on the short and long term. These data will be compared with the recently performed randomized CASCADE trial on…
The aim of this study is to compare the effects of anterior cervical discectomy versus percutaneous plasma discectomy on pain, on global perceived effect, functional status and health-related quality of life in a group of patients with cervical…
This study is designed to evaluate the effectiveness and safety of the MID-C System.
The objectives of this study are to evaluate the safety and performance of the Cadisc*-C Total Cervical Disc Replacement Device in the surgical replacement of the cervical intervertebral discs (C3 to C7) for patients requiring surgical intervention…
Primary objective: To create and validate healthy-subject-specific musculo-skeletal models of the lower extremity. We will also develop a new method using the Positron Emission Tomography (PET) technique that can be used to validate musculo-skeletal…
Assessing the effectiveness and safety of parecoxib compared to placebo in pain relief children undergoing scoliosis surgery
The primary objective is to gain insight into the effects of guided imagery on pain intensity in people with fibromyalgia. Secondary objective is to gain insight into the effects on self efficacy and functional status.
To show whether Active C disc prosthesis is more effective than anterior discectomy with or without interbody fusion 1 year after surgery. Moreover, the incidence of adjacent disc degeneration will be evaluated 5 years after surgery.
To assess if a continued rehabilitation program in the first six weeks post-surgery for patients following a first time is morecost-effective as compared to no further treatment after discharge from the hospital an economic evaluation alongside…
(1) To phenotype chronic low back pain patients in terms of endogenous modulation of pain, central sensitization/facilitation, and the presence of a neuropathic pain component;(2) To assess the effect of a three-month treatment with tapentadol on…
The main objective is to gain insight into the effects of guided imagery on pain, self efficacy and functional status of people with fibromyalgia and into the relationships between these outcome variables.
The objectives of this study are to evaluate the safety and performance of the CAdisc*-L Total Lumbar Disc Replacement Device in the surgical replacement of the lumbar intervertebral discs (L3 to S1) for patients requiring surgical intervention for…
To assess the incidence and severity of embolic events during spinal instrumentation surgery with intraoperative transesophageal echocardiography monitoring.
Before a countermeasure or training can be developed to counteract physical deconditioning it is important to investigate more in detail the magnitude and time course of physical deconditioning and to investigate which outcome measure is most…
To assess the analgesic efficacy, safety, and tolerability of once daily orally administered GRT6005 in a total of 3 fixed doses (i.e., 200 µg, 400 µg, and 600 µg GRT6005) compared to placebo in subjects with moderate to severe chronic LBP.
A study on extent-related outcome and complications for degenerative cervical spinal disease has not yet been performed. Results of this study may form the basis for a guideline regarding the extent of fixation in degenerative cervical spinal…
1. To compare the efficacy of tofacitinib, in doses of 2 mg, 5 mg, and 10 mg BID versus placebo on the ASAS20 response rate at Week 12 in subjects with active AS that have had an inadequate response to previous treatment.2. To estimate the placebo-…
To evaluate the (cost)effectiveness of a classification algorithm, based on patient*s symptoms andclinical presentation, that directs patients with non specific LBP to the therapy (exercise therapy ormanual therapy) that they are most likely to…
The purpose of this study is to evaluate the quality and effect of scoliosis brace treatment, by means of correlating body brace interface pressure and scoliosis correction in combination with quality of life questionnaires.