1125 results
This study has been transitioned to CTIS with ID 2024-513624-42-00 check the CTIS register for the current data. Primary Objective: • To evaluate anti-tumor activity of vimseltinib using Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 by…
This study has been transitioned to CTIS with ID 2023-510353-42-00 check the CTIS register for the current data. The purpose of this first-in-human study is to evaluate the safety, tolerability, efficacy, pharmacokinetics (PK), and pharmacodynamics…
To answer the following questions; (1) What is the estimated effect size of personalized rehabilitation therapy for improving daily functioning in severely fatigued myositis patients, compared to usual care? (2) What are the societal costs of…
To determine whether guided growth of the proximal femur decreases the risk of further hip migration and need for further surgery in cerebral palsy patients.
Primary objective: The effect of LL-BFRT on MRI-based graft maturity after BPTB ACL reconstruction compared to HLRT.Secondary objectives: The effect of LL-BFRT on donor-site morbidity, range of motion, knee stability, PROMs, muscle strength, safe…
This study has been transitioned to CTIS with ID 2024-514907-32-00 check the CTIS register for the current data. To assess the safety and tolerability profile, in the pre- and perioperative period (up to 30 days post-surgery), of combined modality…
The study aims to isolate and culture mesoangioblasts from muscle biopsies of two patient groups suffering from skeletal muscle atrophy to assess their potential for autologous muscle stem cell therapy. To relate this potential to the underlying…
A post marketing surveillance study to assess safety, clinical performance and survival of the uncemented Glenoid Affinis vitamys Uncemented Glenoid Affinis Vitamys total prosthetic shoulder replacement. All implants already bear the CE-marking.
Treatment of lateral knee joint pain with artificial lateral meniscus prosthesis after meniscectomy.
The primary objective of the clinical investigation is to evaluate the safety of the LMP system within 1 year after implantation in terms of adverse events and prosthesis integrity. Outcomes: AEs and prosthesis extrusion on MRI 12 months post-…
To evaluate the long term functional and radiological effects of surgical treatment of Weber type C (AO 44-C1/2/3) fibular fractures
The primary objective of the pilot study is to assess the feasibility of a definitive trial to determine the effect of arthroscopic soft tissue stabilization vs. non-surgical treatment on rates of recurrent anterior …
Primary: To describe shoulder function, local fatigue and pain symptoms around the shoulders in children with FSHD type 1, before and after balanced shoulder therapy. Secondary: To gain insight into the experience of children and parents and the…
Is biofeedback gait training on the Gait Real Time Interactive Lab (GRAIL) feasible in children with mild recurrent clubfoot over 4 years of age? And to explore the effect in achieving clinically relevant immediate and short-term improvements in…
Post Market Clinical Follow-up Study on the Refobacin Revision-3 Bone Cement and its instrumentation
The objectives of this study are to confirm safety, performance and clinical benefits of the Refobacin Revision-3 Bone Cement and its instrumentation, when used in hip or knee revision surgeries, by analysis of standard scoring systems, radiographs…
The primary scientific objective of this multicenter study is to examine if adding a behavioral weight reduction program to pain neuroscience education and cognition-targeted exercise therapy, compared to pain neuroscience education and cognition-…
The primary objective of the CONVEnIENT trial is to investigate the effect of daytime intermittent enteral tube feeding, compared to a standard continuous tube feeding pattern (24-hour/day), on glycaemic control, gastrointestinal function, circadian…
To assess the effectiveness of daily protein supplementation with either a plant based protein blend or a milk protein on top of a standard diet to stimulate integrated muscle protein synthesis rates in healthy older individuals with and without…
Our objective is to design and evaluate proof-of-concept of the WalkWell Gait reTrainer, an affordable, user-friendly continuous gait feedback system, complete with remote patient monitoring capabilities to support clinical care. We hypothesize that…
Primary Objective: To study the association between muscle characteristics (contractile, morphological,biochemical, and histological) and the response to high- and low-load exercise training on muscle strength in patients with rheumatoid arthritis (…
Primary Objective: To assess the effectiveness of an app-based treatment combining physical therapy, graded activity, and pain journaling, in improving health-related quality of life measured with the EuroQol 5 dimensions (EQ-5D-5L) in patients with…