1125 results
To identify the patient profile for Actifuse and for other grafting products used to achieve bone fusion.
To determinate the efficacy and safety of golimumab in rheumatoid arthritis patients in daily clinical practice during 48 months. In addition, the effect of treatment with golimumab on the lipid profile will be monitored during this study.
Primary Objective: The primary goal of this research project is to evaluate the effect of a rockered shoe on walking and running biomechanics in healthy athletes and athletes with Achilles tendinopathy. The reason for using a patient group is that…
To evaluate the efficacy and safety of nilotinib in spondyloarthritis
• Compare bone density between patients with mild haemophilic and those with severe haemophilia*.• Compare the relationship between treatment regimen: prophylactic (high-dose vs. intermediate dose) and on-demand and bone density.• Examine the…
Primary Objectives:• show effectiveness of the SMSC instrument in 3D correction of the spine prior to placement of the implants.The hypothesis is that to achieve de-rotation of the spine without failure of the pedicle screws, de-rotation has to be…
The primary objective for this study is to compare the safety, tolerability and analgesic efficacy of ABT-110 administered subcutaneously (SC) once every 8 weeks (q8w) for a total of 2 doses to placebo in subjects with pain due to osteoarthritis (OA…
To determine the efficacy and the safety of PREOB, a proprietary population of autologous bone-forming cells, in the treatment of non-infected hypotrophic non-union fractures of long bones.
To study the safety and feasibility of adding 6 weeks of orally administered Pazopanib to 25 x 2Gy in 5 weeks preoperative radiotherapy in soft tissue sarcoma patients (to identify the Dose Limiting Toxicity (DLT) and the Recommend Phase II Dose (…
PRIMAIRYThe primary objective of this trial is to evaluate the efficacy of atacicept compared to placeboin preventing new flares in subjects with SLE.SECONDARYSecondary objectives of the trial are:• To evaluate the safety and tolerability profile of…
Please refer to protocol, section 1.2 "Rationale"
The effectiveness of PRP treatment in patients suffering from chronic lateral epicondylitis is still ambiguous. Therefore we study PRP treatment in a double blind randomized controlled trial in a homogeny patient population with respect to duration…
To investigate the effect of anti-IL6 therapy with tocilizumab on subclinical arterial inflammation (endothelial dysfunction) and stiffness in patients with treatment resistant rheumatoid arthritis at baseline and after 6 months treatment
The primary objective is to test the hypothesis that once daily tadalafil administered orally for 48 weeks lessens the decline in ambulatory ability as measured by the 6MWD compared to placebo in boys with Duchenne muscular dystrophy (DMD). Two…
The aim of this study is to investigate the cost-effectiveness of E-Exercise in comparison with usual care of a physical therapist. Research question for this RCT study is: What are the short- (3 months) and long term (12 months) (cost) effects of E…
Primary Objective is to evaluate the long-term safety of sirukumab in subjects with RA who are refractory to DMARDs or anti-TNF* agents.The secondary objectives are to observe the following long-term effects of sirukumab in subjects with RA who are…
To compare the accuracy of syndesmotic reduction on an axial CT-scan postoperatively (reflecting syndesmotic malreduction) after anatomical open reduction and fixation of the posterior malleolar fragment versus no fixation of the posterior fragment…
There is no high-level clinical evidence, with regard to clinical outcome, for the superiority of ESWT versus treatment with needling. The objective of this trial is to compare high-energy ESWT and ultrasound guided double percutaneous needling in…
Study of functional outcome after arthroscopic tenotomy of long head biceps tendon vs. arthroscopic debridement vs. conservative treatment as treatment for degenerative rotator cuff ruptures in patients 65 years or older.
Documentation of the patients' functional recovery and quantification of fusion after implantation of 3-D trabecular titanium cages on the short and long term. These data will be compared with the recently performed randomized CASCADE trial on…