Search for a trial

A Randomized, Double-Blind, Placebo- and Active-Controlled, 4 Period Crossover Study to Evaluate the Effect of Lemborexant versus Placebo on Driving Performance in Healthy Adult and Elderly Subjects.

Primary ObjectiveThe primary objective of the study is to evaluate the effect of lemborexant 2.5, 5, and 10 mg compared to placebo on standard deviation of lateral position (SDLP) during an on-road driving test in the morning following a single dose…

A single dose, randomized, four-way cross-over, bioavailability and food interaction study of PedPRM (Pediatric Prolonged Release Melatonin, Neurim Pharmaceuticals Ltd) and Circadin® tablets in healthy male and female volunteers.

Primary Objective- To demonstrate dose proportionality between 1 mg and 5 mg of PedPRM (Neurim Pharmaceuticals Ltd.) following a single oral dose in healthy male and female volunteers (treatment A and C), under fed conditions.Secondary Objectives-…

(Cost-)effectiveness of a guided online CBT intervention in comparison to care-as-usual for patients with insomnia in general practice

Primary Objective: To determine the effectiveness of guided CBT compared to care-as-usual in treating insomnia in the general practice.Secondary Objective(s): Secondary objectives include investigation of cost-effectiveness. Several variables will…

Effectivity of cognitive behavioral therapy in treating insomnia in a chronic psychiatric population with a depressive disorder.

Will a sleep training consisting of CBT in a chronic, psychiatric population with depressive disorder and insomnia lead to a decline of sleeping problems and a increase in sleep quality? Will the results from a normal and non chronic population will…

Acetaminophen for SLeep Problems in Elderly Patients

Objective: To investigate whether acetaminophen is effective in treating self-reported sleep problems.

Effects of light therapy on sleep, melatonin rhythm and mood in hemodialysis

Measuring the effects of light therapy during hemodialysis on objective en subjective sleep parameters, sleepiness during dialysis, mood and melatonin rhythm. De results of this pilot study can be used to design a larger study on light therapy in…

Sleep problems of adolescents and efficacy of treatment. A study on effective and easily accessible treatment of sleep problems of adolescents.

There are three main questions:1. How effective is internet treatment of insomnia in adolescents compared with group treatment of insomnia and control groups?2. Are the principles of cognitive behavioral therapy of insomnia in adolescents correct?3…

Online self-help CBT for insomnia: With or without feedback?

The objective of this study is to determine whether providing feedback enhances self-help CBT for insomnia.

A double-blind, randomized, controlled, 3-way crossover, pilot study to evaluate the duration of effects on simulated car driving and cognitive performance after a single dose of JNJ-42847922, zolpidem and placebo in healthy subjects

To evaluate the effects of JNJ-42847922, compared to zolpidem and placebo, on driving performance as assessed by the mean difference of standard deviation of lateral position (SDLP) after forced awakening using a validated driving simulator test at…

A randomized, placebo-controlled, 2-way crossover, double-blind study to evaluate the efficacy, safety and tolerability of JNJ-42847922 in subjects with insomnia disorder without psychiatric comorbidity.

The purpose of this study is to see if JNJ-42847922 is useful for treating patients with insomnia without any other psychiatric disease. The safety of JNJ-42847922 will also be studied.

Sleeptraining in substance use disordered patients in clinical addiction care

The objective of this study is the effectiveness of a cognitive-behavioural therapy for insomnia in inpatient abstinent patients in addiction care.

A guided web-based intervention for insomnia: a pilot study

As part of the development of the guided web-based self-help intervention for insomnia we want to conduct a pilot study. The aim is twofold: (1)we want to know how satisfied people are with this course. Specific questions are: what are the…

Evaluation of the cognitive and psychomotor effects of LY2624803 following bedtime dosing in healthy subjects

This study is being performed to evaluate the cognitive and psychomotor effects of the new compound LY2624803 after bedtime dosing.

A self-help method for nightmares

The objective of this study is to validate a newly designed self-help treatment for nightmares. This self-help treatment is based on Imagery Rehearsal Therapy. This treatment will be validated in comparison to an exposure treatment a diary condition…

The regulation of end-tidal carbon dioxide by dynamic rebreathing for patients with central sleep apnea.

The feasibility of the new device is investigated. The primary objective includes the ability to regulate nocturnal PETCO2 in patients with CSAS and the user experiences. Secondary objectives concern the differences in CSAS parameters, e.g. apnea/…

Improving sleep quality, psychosocial functioning, and cancer related fatigue with light therapy (SPARKLE-study).

(1) To examine whether the exposure to BWL yields clinically significant reductions in CRF compared to exposure to dim white light in (non-)Hodgkin survivors. (2) To examine the effect of exposure to BWL compared to DWL on sleep quality and…

Melatonin Against Temazepam in Comparing adverse events in vulnerable elderly Hospitalized patients with sleeping problems

Primary objective: To investigate whether either melatonin or temazepam is superior to placebo in improving subjective sleep quality and to investigate whether melatonin is non-inferior to temazepam in acute hospitalized older patients.Secondary…

Does early identification and treatment of sleep problems
bolster psychiatric therapeutic outcome?

The major aim of the proposed project is to investigate the clinical relevance of early identification and adequate treatment of co-occurring sleep disorders in people suffering from mental disorders. The main questions underlying the present…

Effectiveness and cost-effectiveness of internet-based treatment for insomnia in depressed patients treated at a mental healthcare outpatient clinic.

The current project aims to assess both the effectiveness and cost-effectiveness of an internet-based insomnia intervention (i-Sleep) in addition to usual care for depression, compared to usual care alone, in depressive patients with comorbid…

A single-center, randomized, double-blind, double-dummy, placebo- and active-controlled, 4-way cross-over study to assess next-day driving performance following single and multiple evening administrations of ACT-541468 in middle-aged and elderly subjects.

Primary objective- To evaluate the effects of ACT-541468 on objective simulated driving performance, i.e., the standard deviation of the lateral position (SDLP), after single- and multiple dose administrations (i.e., on Day 1 and Day 4) in the…