19 results
The primary goal of this study is to assess how M4M affects acceptance of antipsychotic depot medication, during the intervention and after terminating the intervention.
The proposed study aims to investigate the effects of a psychomotor assertiveness training by means of a multicentre randomized controlled trial (RCT). Effects will be examined at the behavioural level by means of questionnaires and interviews, and…
Primary:-To assess whether the genetic architecture of this severe SCZ phenotype differs from the broad DSM-based SCZ phenotypeSecondary:-To detect genetic associations with the current severe SCZ phenotype (case-control comparison)-To unravel…
The purpose of this investigation is: • To examine the effect of single and multiple doses of the new drug JNJ-39393406 (the study medication) on absorption, metabolism and excretion by the body after single administration of the drug midazolam.• To…
Primary study objective Is the reduction of 1 to several antipsychotic antipsychotic associated with more relapse? Relapse is measured with the Brief Psychiatric Rating Scale (BPRS) and is defined as: - An absolute increase of> 2 on one of…
1. To compare patient outcomes during follow-up between adherents versus non-adherents with psychoeducation in patients with schizophrenia. We selected *time to (re)hospitalisation* as the most important outcome.2. To assess the prevalence and risk…
Hypotheses of the study:Psycho-education coping skills training is effective in reducing the negative consequences of stigma in people with SMI, in a way thata) quality of life of people with SMI improves;b) social functioning of people with SMI…
In preparation for a multicentre randomized controlled trial (RCT) we want to test the psychomotor assertiveness training in a feasibility study. The aim of this study is threefold: 1) We want to evaluate and improve intervention protocol also using…
HypothesisChildren and adolescents with non-psychotic psychiatric disorders represent a vulnerable group high prone for psychotic symptoms. In contrast with normal populations more pronounced symptom and cognitive profiles will be found predicting…
This study examines two two forms of crisis card: (1) crisis card formulated with an independant consulant, (2) crisis card formulated with a clinician.The background of the comparison of the two forms of intervention is that the crisis card…
The overall aim of the current study is to investigate the efficacy and clinical feasibility of a novel, accessible, transdiagnostic, ecological momentary, compassion-focused intervention for improving emotional resilience to stress (*EMOCOMPASS*)…
To investigate whether methylation patterns/levels and gene expression profiles predict treatment outcome after initiating CLZ.
Primary: To assess whether the genetic architecture of this severe SCZ phenotype differs from the broad DSM-based SCZ phenotype.To predict response and side effects after clozapine intakeSecondary:1. To detect genetic associations with the current…
The VAT study aims to investigate which factors influence and predict the different areas of recovery. VAT also examines how the content of voices that patients hear should be mapped and registered. We examine whether these factors can predict…
The aim of this study is to validate EEG prediction markers of antipsychotic treatment outcome in patients with psychosis. *
In the ASAP study, we aim to investigate pain associated with capillary sampling in a population of patients with serious psychiatric problems, compared to pain associated with standard venous access. This study is a pilot for a planned larger study…
Primary objective of this randomised controlled trial is to compare transition rates to psychosis between individuals who are at UHR for developing psychosis and randomised to treatment with omega-3 fatty acids to those randomised to placebo, as…
The current pilot study intends to establish the effect of a single dose of dGK on relevant (neuro-)electrophysiological (primary outcome: Pre-Pulse Inhibition (PPI); furthermore on resting EEG, on the ERP P300, cognitive, metabolic, inflammatory,…
The main objective of the LIPS study is to use NLP and SLP quantitative features as well as passive sensing data to predict psychotic relapse above chance both at the group and individual levels. The LIPS study will also retrospectively assess, as…