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From shape to wavefront: retrieving optical aberrations from corneal anatomy

To determine the aberration pattern of the cornea from its shape.

Bioavailability of lutein from a lutein-enriched egg-yolk-beverage and its dried re-suspended versions.

The primary objective of this study is to investigate whether consumption of a dried lutein-enriched egg-yolk containing beverage significantly increases serum lutein concentration in healthy volunteers.A secondary objective is to investigate…

Comparison of monocular implantation of the Acrysof Toric T2 intraocular lens with a standard monofocal intraocular lens in subjects with cataracts and low corneal astigmatism

- Analyse the effect of the toric T2 intraocular lens on quality of vision, compared to a standard monofocal intraocular lens. - Analyse the satisfaction of patients with their visual acuity with the toric T2 intraocular lens, compared to a standard…

A randomised, subject-masked evaluation of visual function after bilateral implantation of two types of presbyopia-correcting multifocal intraocular lenses (IOLs): the Symfony-study

Primary Objective: The primary objective of this study is to compare the postoperative visual outcomes in a series of patients bilaterally implanted with the AT LISA tri 839MP IOL versus those bilaterally implanted with the TECNIS® Symfony IOL (…

VERION vs conventional, manual ink-marking in toric IOL implantation

The primary objective of the study is to compare the accuracy in toric IOL alignment when using the VERIONTM Measurement Module and VERIONTM Digital Marker for alignment of the toric IOL or the conventional manual ink-marking procedure. The…

Causes, risk factors, complications and treatment of uveitis in childhood

First, to develop a diagnostic method for non-infectious uveitis in childhood. Second, to analyze iris and ciliary body tissues of children with uveitis on the presents of inflammatory infiltrate. The results of this study will contribute in the…

The Aqueous Humor Ferritin Level in Hereditary Hyperferritinaemia-Cataract Syndrome

To determine the normal ferritin level in the anterior chamber, and to compare this with the ferritin level in HHCS patients.

Pathogenesis, diagnostics and complications of uveitis in childhood.

First, to develop a diagnostic method for non-infectious uveitis in childhood. Second, to analyze iris and ciliary body tissues of children with uveitis on the presents of inflammatory infiltrate. The results of this study will contribute in the…

A Phase 3 Randomized, Double-Masked, Placebo-Controlled Study of the Pharmacokinetics of OMS302 and the Effect of OMS302 on Intraoperative Pupil Diameter and Early Postoperative Pain in Subjects Undergoing Intra Ocular Lens Replacement with Phacoemulsification.

The co-primary objectives of this study are to evaluate the effect of OMS302 compared to placebo when administered in irrigation solution during phacoemulsification and intraocular lens replacement on: • Intraoperative pupil diameter.• Pain during…

Prospective, open label, single arm, First in Human (FIH) clinical study to assess Safety and efficacy of the CorNeat Keratoprosthesis for the treatment of corneal blindness

The objective of this clinical study is to prove the safety of the CorNeat KPro.

Effectiveness of customized corneal crosslinking versus standard corneal crosslinking in patients with progressive keratoconus

The objective of this project is to evaluate whether the effectiveness of customized cross-linking (cCXL) is non-inferior to the standard cross-linking protocol (sCXL).

AN OPEN-LABEL MULTICENTER PHASE 2 CLINICAL SAFETY INVESTIGATION OF THE ENDOART® IMPLANTATION IN SUBJECTS WITH CHRONIC CORNEAL EDEMA

To evaluate the safety of EndoArt® in subjects with chronic corneal edema.

A Phase 3, Multicentre, Double-masked, Randomised Study to Evaluate the Efficacy and Safety of Intravitreal OPT-302 in Combination with Aflibercept, Compared with Aflibercept Alone, in Participants with Neovascular Age-related Macular Degeneration (nAMD) (COAST)

This study has been transitioned to CTIS with ID 2024-512880-30-00 check the CTIS register for the current data. To determine the efficacy of intravitreal 2.0 mg OPT-302 when administered in combination with intravitreal 2.0 mg aflibercept, in…

Whole Exome & Whole Genome Sequencing Analysis to Explore Familial Keratoconus

To identify genetic variants for the development and progression of keratoconus using Whole Exome Sequencing and Whole Genome Sequencing approaches on keratoconus families with index patients originating from the Rotterdam Eye Hospital and Erasmus…