36 results
2.1 Primary objectives2.1.1 Cross-sectional part• Technical evaluation of the functional and structural outcome measures to support a biomarker qualification by regulatory authorities and payers. 2.1.2 Longitudinal part • Assessment of prognostic…
The main objective is to determine whether the administration of allogeneic serum micro eye drops using the mu-Drop device is non-inferior to the conventional sized drops in terms of effectiveness and safety.
Primary Objective:To demonstrate the long term safety of one or two ACLSCT(s) in patients suffering from moderate to severe LSCD secondary to ocular burns. Secondary Objectives:• To evaluate the long-term efficacy of one or two ACLSCT(s), the degree…
The aim of the study is to document the presence and/or post-operative development of PVD and to assess its influence on the incidence of PRD in myopic patients in a time period of three and five years after lens surgery.
The purpose of this study is to investigate how safe the new compound FM101 is and how well it is tolerated when it is administered to healthy volunteers. FM101 has not been administered to humans before. It has been previously tested in the…
Measurement of retinal blood flow in glaucoma patients before and after Baerveldt Shunt Implantation
The aim of this study is to explore the capability of the RFI to measure short and long term changes in retinal blood flow velocity and oximetry maps before and after a BGI and to compare these results with OCTA measurements.
The primary objective of this pilot study is to determine the clinical value of ocular MRI for patients with the following ocular conditions:- Glaucoma treated with a Baerveldt implant- Visual field loss- Diplopia
To demonstrate choroidal thickness of emmetropic and myopic CSC patients to be significantly different.
To establish the proportion of complete vitreoschisis removal with PVA.
This exploratory study is designed to evaluate several depatuxizumab mafodotin-related OSE management strategies.The main objective of this trial is to estimate the percentage of subjects in each prophylactic treatment arm who require a change in…
The primary objective is to evaluate changes in ICP due to acetazolamide using a noninvasive method of ICP measurement and to compare this with changes in IOP. Healthy controls will be used to control for any effect of diurnal fluctuations.
The purpose of this study is to investigate how safe and effective the new drug conbercept given as intravitreal injections (*study drug*) is when compared with Eylea® injections in patients with neovascular *wet* age-related macular degeneration (…
The goal of this study is to characterize the natural course of IRDs that can potentially be modulated by future therapy. Second, this study aims to understand the relationship between various structural and functional biomarkers in potentially…
1. The primary objective of this study is to confirm the utility of the oVEMP cross-sectionally for the diagnosis of MG by reproducing the findings of Valko et al. in our cohort of MG patients and three control groups: healthy controls, controls…
To evaluate the effectiveness and costs of immediately sequential bilateral cataract surgery (ISBCS) compared to delayed sequential bilateral cataract surgery (DSBCS; usual care) in order to determine whether ISBCS is an effective and cost-effective…
Primary Objectives: - Assess the feasibility and clinical value of 7T MR to provide a more detailed anatomic description of the anterior visual pathway in NFMA patients compared to conventional MRI. - Assess the feasibility of high-field MRI to…
To evaluate the natural progression of disease over time in USH1B patients using visual field testing and best corrected visual acuity.
To demonstrate whether a statistically significant difference exists between T2D patients with and without DR.
Main objective: To map the natural course of the visual and hearing deterioration in Usher Syndrome type 2 for upcoming genetic therapy studies.Secondary Objective 1): To determine a. the necessary type of (combined) examinations, b. the sample size…
Primary Objective:The primary objective of this study is to demonstrate the long-term (3 years) favorable visual acuity and adverse event outcomes for the Clareon IOL compared to historical SPE rates as reported in EN ISO 11979-7:2014.Secondary…