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Autonomic and cardiac function in end stage renal disease patients: A pilot study

The main objective of this pilot study is to determine the effects of vascular access construction on autonomic and cardiac function.

Safety of allogeneic bone marrow derived mesenchymal stromal cell therapy in renal transplant recipients

To study whether selected allogeneic bone marrow derived MSCs are safe by assessing the composite end point Biopsy Proven Acute Rejection (BPAR)/ graft loss at 12 months

ADOLESCE-NT: More rapid deterioration of renal function after renal transplantation in adolescence: effect of the endocrine system on immunological and pharmacokinetic factors

Answering the question if there are any associations between hormonal status in adolescence on the one hand, and immunological reactivity and pharmacodynamics on the other hand; and if such associations can explain the more rapid deterioration of…

A prospective Randomized Controlled Trial to Evaluate the Primary Prevention of sudden cardiac death using implantable cardioverter defibrillators in dialysis patients.

The main objective of this study is to assess whether ICD therapy in dialysis patients reduces sudden (arrhythmogenic) cardiac death. The first secondary end point is to compare total mortality death between the two groups. An other is to evaluate…

Ammonium chloride test and distal urine acidification

to determine if there is an alternative mechanism for urine acidification in men in response to NH4Cl other than that through ENaC

A Maastricht Contrast-Induiced-Nehropathy Guideline study (AMACING): prevention guidelines - appropriate and cost effective?

The AMACING study aims to evaluate the (cost) effectiveness of guideline prescribed intravenous prophylactic hydration in the prevention of: CIN, decrease in renal function, renal damage, 30-day morbidity and 30-day mortality; taking into account…

A multicentre randomised controlled trial to compare the efficacy of ex-vivo oxygenated hypothermic machine perfusion with non-oxygenated hypothermic machine perfusion of kidneys from donors older than 50 years of age and donated after circulatory death.

To compare the effect of oxygenated versus non-oxygenated hypothermic machine perfusion of grafts of DCD category III (awaiting circulatory death - controlled), kidneys aged 50 years or older on kidney graft function.

A Randomized, Multicenter, Double-Blind, Parallel, Placebo-Controlled Study of the
Effects of Canagliflozin on Renal Endpoints in Adult Subjects With Type 2 Diabetes
Mellitus ('CANVAS-R')

Primary objectiveIn subjects with T2DM receiving standard of care but with inadequate glycemic control and at elevatedrisk of cardiovascular (CV) events to assess the effect of canagliflozin compared to placebo onprogression of albuminuria.Secondary…

Insights in proximal and distal tubular iron reabsorption by studies on urinary iron excretion in human health and disease

We aim to gain insights in proximal and distal tubular reabsorption of iron, transferrin, NTBI and labile plasma iron (LPI). To this purpose, we will study urinary iron, transferrin, NTBI and LPI concentrations relative to urinary creatinine…

*Effects of Butyrate on Intestinal permeability & inflammation, Intellectual performance, Immune activation and systemic Inflammation in renal disease.

Investigate whether restoration of intestinal butyratelevels improves the intestinal barrier function and decreases the inflammatory status in CKD patients.

A multi-center randomized, open label, controlled study in primary liver transplantation comparing long term renal function in recipients treated with standard dose extended release tacrolimus alone and recipients treated with a combination of low dose extended-release tacrolimus and low dose sirolimus.

To evaluate the effectiveness and safety of concentration controlled combination of once daily dosed low-dose sirolimus (trough levels: 3-5 ng/ml) and extended-release tacrolimus (trough levels:3-5 ng/ml), in order to provide superior renal function…

Cardiovascular (CV) risk prediction and CV biomarkers in renal transplant recipients treated with belatacept compared to calcineurin inhibitors (CNI).;Open randomized 12 month study.

The goal of this study is to prove whether kidney transplant recipients can reduce their risk of cardiovascular disease bij converting to Nulojix.

A 24 month, multicenter, randomized, open-label safety and efficacy study of concentration-controlled everolimus with reduced calcineurin inhibitor vs mycophenolate with standard calcineurin inhibitor in de novo renal transplantation- Advancing renal TRANSplant eFficacy and safety Outcomes with an eveRolimus-based regiMen (TRANSFORM)

Primary: to evaluate the effect of everolimus with reduced exposure CNI versus MPA with standard exposure CNI on the binary composite of treated biopsy-proven acute rejection (tBPAR) or eGFR < 50mL/min/1.73m2 at Month 12 post-transplantation.…

Protection against ischemia-reperfusion injury (I/RI) by ischemic postconditioning in non-heart beating kidney transplantation

To find out if there is a protective effect of postconditioning on ischemia reperfusion-injury in kidneytransplantation.

Heart rate variability in patients with overactive bladder or stress urinary incontinence.

The goal of the study is to investigate the difference between heart rate variability in patients with overactive bladder and patients with stress incontinence without overactive bladder, and also the difference in heart rate variability with empty…

Temporal dynamics of tryptophan and symptoms of depression and fatigue in dialysis patients: a time-series approach.

The objective of this pilot study is to investigate the association between hemodialysis-associated changes in tryptophan levels and changes in symptoms of depression and fatigue, and the temporal dynamics between depression and fatigue.

The antihypertensive effect of spironolactone in oligo-anuric haemodialysis patients.

1. to study the effect of spironolacton and triamterene on blood pressure in anuric hemodialysis patients.2. to study the effect of treatment on body weight, serum elektrolytes, 24-hours sodium excretion, plasma aldosterone and renin concentrations…

Microvascular perfusion in renal ischemia/reperfusion injury during clinical kidney transplantation: an observational study.

First, to determine the extent to which microcirculatory perfusion defects occur during clinical kidney transplantation. Second, to study the relationship between these events and kidney function, inflammation and renal cellular injury. Third, to…

Prevention of Acute Radiation cystitis by using Intra-vesical chondroitin Sulphate.

The primary objective of this study is to evaluate whether preventive intravesical instillations with 0.2% chondroitin sulphate solution reduce bother related to acute radiation cystitis symptoms patients undergoing pelvic radiotherapy.

Cystine Lithiasis in the Netherlands;
Clinical and genetic aspects

- To evaluate the demographic, clinical and genetic characteristics of all known patients with a diagnosis of cystinuria and cystine nephrolithiasis in the Netherlands.- To evaluate the relationship between genotype and phenotype of all known…