89 results
The primary objective of the study is to assess the efficacy and safety of 3 different treatment arms (bevacizumab alone, atezolizumab-bevacizumab combination with acetylsalicylic acid and atezolizumab-bevacizumab combination with placebo) in…
The primary objective is to increase the percentage of elderly patients with ovarian cancer who complete standard or adapted therapy by using geriatric screening prior to start of therapy and to assess whether geriatric screening tests provide a…
This study has been transitioned to CTIS with ID 2023-508722-99-00 check the CTIS register for the current data. Primary objective:- Investigate the safety of replacing inguinofemoral lymphadenectomy by chemoradiation in early stage vulvar cancer…
Primary Objectives: Determine oncologic outcomes after fertility-sparing treatment in AYAs with cervical, ovarian or endometrial cancer (Q1). Determine fertility and obstetric outcomes after fertility-sparing treatment in AYAs with cervical, ovarian…
This study has been transitioned to CTIS with ID 2023-507230-24-00 check the CTIS register for the current data. To assess the feasibility of preserving fertility in women with 2018 FIGO stage IB2 cervical cancer with lesions measuring >2 cm…
This study has been transitioned to CTIS with ID 2023-508832-68-00 check the CTIS register for the current data. Dose escalation: To establish the MTD and RP2D of tisotumab vedotin in combination in subjects with cervical cancer Dose expansion:…
The primary objective of this study is to assess the feasibility of EM-navigation for gynaecological brachytherapy catheter placement.
This study has been transitioned to CTIS with ID 2024-516327-14-00 check the CTIS register for the current data. This study is evaluating the preliminary efficacy of UV1-olaparib-durvalumab combination against both olaparib as monotherapy and…
This study has been transitioned to CTIS with ID 2023-506361-56-00 check the CTIS register for the current data. This study is designed to assess the efficacy and safety of pembrolizumab monotherapy compared with SoC platinum doublet chemotherapy…
This study has been transitioned to CTIS with ID 2024-516736-10-00 check the CTIS register for the current data. Based on the success of the pilot feasibility study, we propose a follow-up efficacy study to explore neo-adjuvant ICB therapy as…
Primary objective:- To determine if TTFields at 200 kHz to the abdomen and pelvis with weekly paclitaxel in the treatment of recurrent ovarian cancer patients prolongs the overall survival of patients, compared to weekly paclitaxel treatment alone.…
Primary objective:- To determine the difference in mean dose (Gy) to pelvic bones (whole pelvic contour), and the difference in the mean V15Gy-bowelbag volume in cc (according to EMBRACE bowel bag definition) between photon and proton therapy in…
The primary objective of this study is to examine whether MIS is non-inferior to laparotomy in terms of disease free survival (DFS) in women with advanced stage EOC that received 3 to 4 cycles of NACT.
The primary objective of the study is to estimate the clinical benefit of cemiplimab + ISA101b after progression on first line chemotherapy, as assessed by objective response rate (ORR).The secondary objectives of the study are:• To characterize the…
This study has been transitioned to CTIS with ID 2023-503267-42-00 check the CTIS register for the current data. Primary:• 3 year recurrence free survival (RFS), in patients with MMRd HREC Secondary:• RFS (median and at 5 years)• OS (median, 3yr,…
Primary objectiveThe main objective of the trial is to assess in High Grade Undifferentiated Uterine Sarcoma (HGUS), High Grade Endometrial Stromal Sarcoma (HGESS), High Grade Leiomyosarcomas (HGLMS) and High Grade (HG) adenosarcoma , the efficacy (…
This study has been transitioned to CTIS with ID 2024-514711-99-00 check the CTIS register for the current data. To evaluate BSA-based versus concentration-based OVHIPEC with cisplatin in patients with advanced-stage ovarian cancer.
The primary aim of this study is to investigate the effect of honey on the clearance of the hr-HPV virus in patients with CIN II.Secondary, the effect of honey on the normalization of CIN lesions, the role of the vaginal microbiome, the local immune…
The primary objective of this trial is to determine clinical efficacy of Vvax001 in CIN3 patients.