270 results
The primary objective of this study is to evaluate the safety in terms of complication rate of IRE in the treatment of colorectal liver metastasis/es <3,5 cm in patients undergoing surgical resection (metastatectomy, segmental liver resection…
The aim of the study is to test the hypothesis that susceptibility to and severity of certain infectious and inflammatory diseases can be explained by the interaction between the genome, microbiome and immunological responses: i.e. presence of…
Primary Objective:To determine the effect of the Topical Gentamicin-Collagen Sponge (gentamicin-sponge) in combination with systemic antibiotic therapy compared to placebo-sponge and no-sponge, both in combination with systemic antibiotic therapy on…
1. To optimize sorafenib treatment in patients with HCC and CP-B liver cirrhosis by exploration of sorafenib exposure, its variability and predictive factors .Secondary:2. To assess the relation between sorafenib exposure and both toxicity and…
To assess the time to progression after TACE-DEB and after SBRT in a comparable population of patients diagnosed with HCC.
To determine safety and technical feasibility of stereotactic radiotherapy for locally advanced and locally recurrent pancreatic carcinoma.
In this study we will explore changes in the hepatic function after stimulation of hepatic cells with an oral food challenge, the **hepatocyte reserve capacity**. Moreover, we will explore potential differences in the hepatocyte reserve capacity…
The primary objectives of the study are as follows:• To investigate the effect of recAP on renal function and related clinical parameters in patients with SA-AKI.• To determine the therapeutic dose(s) of recAP to support the pivotal Phase 3 program.…
The primary study objective is to compare the efficacy, as assessed by overall survival, of surgery and neo-adjuvant chemotherapy to surgery alone in patients with resectable liver metastases of colorectal cancer and a high clinical risk score.…
The primary objective of this project is to evaluate the primary and secondary technique effectiveness of IRE for centrally located colorectal liver metastases that are neither amenable for resection nor for other local ablation methods due to the…
Primary objective: To compare the NP microbiome composition and the presence of viruses in children hospitalized for a LRTI to the NP microbiome composition and the presence of viruses in healthy age- and gender-matched controls. Secondary…
To investigate whether raw milk, pasteurized milk or ultra-heat treated (UHT) milk is able to enhance the systemic immune response as induced by oral cholera vaccination, in comparison to regular vaccination. Oral vaccination can also induce an…
Primary objectives:* To evaluate efficacy of adjuvant 166Ho-radioembolization (166Ho-RE) after systemic 177Lu-dotatate in a non-comparative phase II study Secondary objectives:* To establish the safety and toxicity profile of adjuvant 166Ho-RE after…
The objective of the study is to assess the additional value of monitoring segmental liver function with HBS in patients undergoing SIRT.
1. To assess the incidence of pulmonary infiltrates by means of low dose CT-scan in patients with a high clinical suspicion of CAP but with a normal chest x-ray 2. The levels of biomarkers (CRP, PCT, White blood cell count) will be compared to the…
The generic objective of the study is to explore associations between exposure to livestock farms and potential health effects. This study will focus on 1) respiratory health effects, 2) Livestock associated infections (zoonoses), 3) Carriage of…
1) To obtain insight into the age-specific seroprevalence (immunity) for selected vaccine-preventable diseases among adult refugees in order to determine the need for targeted vaccination campaigns among identified risk groups (age, country of…
Determination of the seroprevalence and occupational risk factors for zoonotic transmission of hantavirus (including SEOV) and pathogenic Leptospira in professional groups that have high-risk contact with muskrats and/or coypu and the bycatch of…
Primary objective • To determine the overall response rate of two PHP with an at least 6 week interval and 3 mg/kg melphalan in irresectable liver metastases patients. • To determine the percentage of patients qualifying for resection. Secondary…
Primary Objectives:1) To determine immunogenicity of NIP vaccines in preterm infants when vaccinated according to the current Dutch NIP schedule and with rotavirus vaccine following the RIVAR study.2) To unravel the mechanism of immature host…