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A Phase 3 Study Comparing Daratumumab, Lenalidomide, and Dexamethasone (DRd) vs Lenalidomide and Dexamethasone (Rd) in Subjects with Previously Untreated Multiple Myeloma who are Ineligible for High Dose Therapy

The primary objective is to compare the efficacy of daratumumab when combined with lenalidomide and dexamethasone (DRd) to that of lenalidomide and dexamethasone (Rd), in terms of progression-free survival (PFS) in subjects with newly diagnosed…

Administration of immune checkpoint inhibitors through an elastomeric pump. A patient preference study and cost analysis.

The primary objective of this study is to evaluate the patient preference for either ICI-B or ICI-P. Secondary objectives are: to assess patient satisfaction with ICI-B and ICI-P, to establish the safety of ICI-B and ICI-P to establish the…

A Randomized Controlled Trial on Additional Treatment for Isolated Local Pancreatic Cancer Recurrence Using Stereotactic Body Radiation Therapy

To improve survival after recurrence in patients with isolated local PDAC recurrence using local ablative treatment with SBRT inaddition to standard of care.

Setup and intra-fractional motion measurements using surface scanning in head and neck cancer patients

The aim of the study is to investigate the clinical feasibility of irradiation without a mask for head and neck cancer patients. Optical surface scanning will be used and the set-up accuracy, intra-fractional motion, patient friendliness, and…

Assessing optimal treatment settings for the ablation of locally advanced pancreatic cancer with CT-guided percutaneous irreversible electroporation: a randomized feasibility study.

The objective of this study is to compare two IRE protocols for the treatment of LAPC that are currently being used in clinical treatment, to allow for the determination (based on survival and co-morbidity) of the optimal treatment protocol for IRE…

Evaluation of a Cone-beam CT scanner for Image Guided Radiotherapy.

The main objective of this study is to evaluate the image quality of a new cone-beam CT imaging system that will be used to acquire images of a wide selection of anatomical locations in patients receiving radiotherapy for cancer.

A Phase III, Randomised, Double Blind, Placebo Controlled, Multicentre Study of Maintenance Olaparib Monotherapy in Patients with gBRCA Mutated Metastatic Pancreatic Cancer whose Disease Has Not Progressed on First Line Platinum Based Chemotherapy

Protocol v1.0 31-Mar-2014, paragraph 2.1-2.4, pages 37-39:The primary objective of this study is: - To determine the efficacy of Olaparib maintenance monotherapy compared to placebo by progression free survival (PFS).The secundary objectives of this…

A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial of Nirogacestat
Versus Placebo in Adult Patients with Progressing Desmoid Tumors/Aggressive Fibromatosis
(DT/AF).

Primary:To determine the efficacy (as defined by progression-free survival [PFS]) of nirogacestat in adult participants with progressing DT/AF.Secondary:To evaluate the safety and tolerability of nirogacestat in adult participants with progressing…

A Phase 1b-2 study of Mitomycin-C / Capecitabine chemoradiotherapy combined with Ipilumimab and Nivolumab or Nivolumab monotherapy as bladder sparing curative treatment for muscle Invasive bladder Cancer: the CRIMI study.

This study has been transitioned to CTIS with ID 2023-509460-19-00 check the CTIS register for the current data. *In the phase Ib study: to assess the feasibility and safety of the addition of nivolumab and/or ipilimumab to MMC/capecitabine…

Cross-tumoral Phase 2 clinical trial exploring Crizotinib (PF-02341066) in patients with advanced tumours induced by causal alterations of either ALK or MET.

Primary objective* To study the antitumor activity and safety of crizotinib across predefined tumor types in patients whose tumors are harboring specific alterations in ALK and/or METSecondary objectives* To study the specificity of the kinase…

A randomized, double-blind, placebo-controlled, 2-arm Phase III study to assess efficacy and safety of xevinapant and radiotherapy compared to placebo and radiotherapy for demonstrating improvement of disease-free survival in participants with resected squamous cell carcinoma of the head and neck, who are at high-risk for relapse and are ineligible for high-dose cisplatin

This study has been transitioned to CTIS with ID 2023-508528-36-00 check the CTIS register for the current data. The purpose of this study is to demonstrate improvement in Disease-Free Survival (DFS) with xevinapant compared to placebo when added to…

Demonstrating the (cost-)effectiveness of a personalized live-remote exercise intervention for cancer survivors using a super umbrella randomized controlled trial:
the LION-RCT

The primary objective of the LION RCT is to assess the (cost-)effectiveness of a personalized, live-remote exercise intervention for cancer survivors on Health-Related Quality of Life (HRQOL) and the participants* main, self-reported side-effect.…

Detecting cancers Earlier Through Elective plasma-based CancerSEEK
Testing - Ascertaining Serial Cancer patients to Enable New Diagnostic
II (DETECT-ASCEND 2)

The primary objective of this study is to obtain clinically characterized, whole blood specimens from subjects with a new or suspected diagnosis of cancer (cancer subjects) and from subjects who do not have a diagnosis of cancer (healthy) to develop…

Microsampling for therapeutic drug monitoring of imatinib, dasatinib, nilotinib, gilteritinib, midostaurin, and venetoclax

The primary objective is to perform a clinical validation of dried blood spot microsampling of imatinib, dasatinib, nilotinib, gilteritinib, midostaurin, and venetoclax. The secondary objective is to test the feasibility of home monitoring (…

Physical prehabilitation in patients with head and neck cancer scheduled for a laryngectomy; a feasibility study

The aim of this study is both a feasibility study to gain a comprehensive understanding of the feasibility, satisfaction and impact, and trends of the effects of a physical exercise and nutritional intervention in patients who will be treated by a…

Isolation of T cell receptors from human papilloma virus (HPV)-reactive or other tumor-reactive T cells from patients with oropharyngeal, cervical or vulvar cancer

The primary objective of this study is the isolation of TCRs from HPV-reactive or other tumor-reactive T-cells that were present in the tumor and/or the blood of patients with cervix, vulva, or oropharyngeal cancer. The secondary objective is to…