85 results
2 Objectives2.1 Primary objective •To evaluate FAZA-PET/CT as a prognostic factor of the loco-regional control rate at 2 years in HNSCC patients receiving chemo-radiotherapy ± nimorazole.•Time to locoregional recurrence is counted from the day of…
The UPGRADE-RT trial will investigate whether de-escalation of the elective radiation dose and introduction of an intermediate dose-level in the treatment of head and neck cancer will results in less radiation sequelae and improved quality of life…
To study the diagnostic capacity of DW-MRI for detecting recurrence in patients with suspicion of recurrent or persistent HNSCC after initial (chemo)radiation. This study aims to enhance early, low cost detection of recurrence and avoid futile…
An alternative for guide-wire localisation might be the use of radio-active seed (I-125) implantation. This marker can easily be identified by means of a gamma-probe. This radio-active seeds are cilindric capsules (approximately 4 mm with a diameter…
To explore the association between MBL level at baseline and the incidence of febrile neutropenia.
To evaluate if a low-carbohydrate diet leeds to less physiological FDG-uptake in the myocard. Patients on a low-carbohydrate diet will be compared to patients without such a diet.
Primary:- Can carboplatin exposure in children be predicted by taking the plasma concentrations of creatinine of cystatine C into account?Secundary:- Which is the effective carboplatin exposure in the current pediatric treatment protocols?- Is there…
- To determine the prevalence of (pre)cachexia - To determine whether potential biomarkers of pre-cachexia can be identified
To determine the usefulness of pa-pCTLDCT to depict the average anatomy in the head/neck area during the first week of treatment, compared to standard pCT.Secondary objectives are to determine if pa-pCTLDCT has better correlation than standard pCT…
Primary objectives: To examine the ability of functional imaging signal changes over the course of treatment to distinguish patients with and without local recurrenceSecundary objectives:To examine the correlation between the different imaging…
Primary objective * To determine the maximum tolerated dose and recommended dose of metformin plus chloroquine in patients with IDH1/2MT glioma, IHCC and CS Secondary objectives * To describe the toxic effects of metformin plus chloroquine in…
Primary Objective:To investigate the diagnostic value of FDG-PET-CT and DW-MRI (EPI and non-EPI technique) applied 2 weeks after the start of primary chemoradiotherapy for HNSCC to predict locoregional response in the primary tumor and cervical node…
To compare the performance and diagnostic accuracy of two EUS-guided tissue acquisition devices; a 25G Echotip Ultra Fine Needle Aspiration (FNA) device and a new, more flexible, 20G Echotip ProCore Fine Needle Biopsy (FNB) device.
Primary Objectives1. To assess the safety and tolerability of ascending doses of a single IV injection of OTL-0382. To assess the efficacy of ascending doses of a single IV injection of OTL-038 in detecting ovarian, renal cell and endometrial cancer…
In our opinion, CTCs could serve as a pharmacodynamic marker to monitor anti-cancer therapy in clinical trials. Encouraging results, that show that CTCs have pharmacodynamic properties, were recently found in a prospective trial in which CTC number…
1) To study whether [11C]docetaxel uptake by tumours predicts tumour uptake of therapeutic docetaxel.2) To study the effects of therapeutic docetaxel on venous metabolite fractions of [11C]docetaxel.3) To study the relation between tumour blood flow…
1. To explore whether the intraoperative combination of a portable gamma camera for real time imaging and a 99mTc nanocolloid/ICG cocktail for simultaneous radioactive and fluorescence detection is suitable to retrieve sentinel nodes in difficult…
The primary objective of this study is to establish the sensitivity and specificity of an oral uracil loading test as a potential screening tool for DPD deficiency
To determine the test-retest variability of quantitative hypoxia imaging with FAZA-PET, both in untreated subjects (track A) and during radiotherapy (track B). The purpose of this study is to validate FAZA-PET as a selection criterion for…
The accuracy of the different imaging modalities will be assessed with histopathology as the reference. Further, histopathology will be used to estimate the microscopic extension of the tumour in the surrounding tissue. The topological…