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Nutritional prehabilitation in head and neck cancer patients with sarcopenia: a randomized controlled trial

To investigate the effect of nutritional prehabilitation on adverse events in patients with locoregionally advanced head and neck cancer, with low to medium risk of malnutrition and with radiological sarcopenia. To evaluate its effect on patient-…

*improving outcome of patients with squamous cell ESophageal CArcinoma by dose escaLATion using high-prEcision mr-guided radiotherapy (ESCALATE): a phase 1 dose finding trial*

The main objective of this study is to determine the maximum tolerated dose (MTD) of 2-fraction boost MRI-guided radiotherapy (MRgRT) for patients with SCC following CROSS therapy. The secondary objectives are feasibility, non-dose limiting toxicity…

Breathing guidance effectiveness for abdominal and thoracic MR imaging UMC Utrecht

To assess the impact of using breathing instructions while performing motion-compensated MR imaging of lesions in the thorax or abdomen aimed at radiotherapy treatment planning as compared to motion-compensated scans without instructions and free-…

HypoPRIME

Determine the safety (oncological outcome and toxicity) of an comprehensive treatment combining recent advances in the treatment of high risk prostate cancer

Thermoradiotherapy for locally Advanced head and Neck Cancer patients - A phase I dose finding study (TANCA-I)

Primary Objective: To determine the recommended phase II dose (RP2D) of thermoradiotherapy in LA-HNSCC patients. Secondary Objective(s): • Evaluate the Local control, Disease Free Survival and Overall Survival of thermoradiotherapy. • Objective…

Detection of upper GI tumour depth and demarcation by quantified fluorescence molecular endoscopy using systemic administration of ICG during endoscopic submucosal dissection

The primary objective is to evaluate the feasibility of ICG-enhanced near-infrared qFME to determine tumour demarcation and tumour depth in upper GI tumours (e.g. HGD or superficial oesophageal and/or gastric adenocarcinoma (T1)) during ESD.

Dose-intensified Image-Guided Fractionated Radiosurgery for Spinal Metastases (DOSIS)

To determine whether a sustained pain relief can be achieved with dose intensified hypofractionated image guided radiosurgery in patients with vertebral metastasis and a longer life expectancy

Prognostic IntraOperative biomarkers ideNtification in tumor rElatEd suRgery

Our measurement focuses on capturing neuronal activity at single-neuron resolution in the peritumoral cortex of glioma patients using cortical depth electrodes. It is well-established that gliomas can remodel the surrounding brain tissue, leading to…

Immunotherapy for dMMR glioma

To identify predictors for nivolumab response in de novo Mismatch Repair Deficient (dMMR) gliomas

Isolation of T cell receptors from human papilloma virus (HPV)-reactive or other tumor-reactive T cells from patients with oropharyngeal, cervical or vulvar cancer

The primary objective of this study is the isolation of TCRs from HPV-reactive or other tumor-reactive T-cells that were present in the tumor and/or the blood of patients with cervix, vulva, or oropharyngeal cancer. The secondary objective is to…

Comparison of *lesion by lesion* and field photodynamic therapy in the prevention of actinic keratoses: a randomised, split face, single blind pilot study

To compare the efficacy of lesion to lesion treatment with field treatment with photodynamic therapy in actinic keratoses of the face or scalp Primary Objective: • Relapse rate of AK and incidence of new lesions at 9 months after PDT treatment •…