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The yield of a yearly surveillance program for the early detection of pancreatic cancer and its precursor lesions in high-risk individuals

Within the framework of a longitudinal follow-up study, we aim to determine the excess number of detected and surgically resected high-grade premalignant lesions and early stage pancreatic cancers resulting from yearly testing using EUS in a cohort…

Effect of food additive E171 (titanium dioxide) on the development of colorectal cancer, an early biomarkers research.

In this intervention study, the primary aim is to evaluate the influence of E171 exposure on the gene expression profile in rectal biopsies. In addition, inflammatory markers such as ROS in the rectal epithelium will be measured as secondary outcome…

Fluid hydration to prevent post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis: the FLUYT-prevent trial. a multicenter randomized controlled superiority trial.;Pancreatic duct stent placement to prevent post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis in patients with unintended PD-wire cannulation: a multicenter prospective cohort

FLUYT: To investigate whether aggressive rehydration with RL during ERCP prevents PEP and will be cost-effective.FLUYT-2-PDS: To investigate if PDS placement further reduce the risk of the development of PEP in patients with unintended PD-wire…

Preoperative radiotherapy in patients at very high risk of postoperative pancreatic fistula after pancreatoduodenectomy (FIBROPANC-1): a multicenter phase II study

To investigate the feasibility and safety of preoperative stereotactic radiotherapy of 4cm pancreas in patients undergoing pancreatoduodenectomy at high risk of developing postoperative pancreatic fistula (>25%).

The European Polyp Surveillance study

1. To investigate the optimal time interval for colonoscopy surveillance in patients with low-risk and high-risk adenomas (EPoS I trial and EPoS II trial); 2. To evaluate the yield of surveillance in patients with clinically relevant serrated polyps…

Randomized, Placebo-Controlled, Double-Blind, Multicenter Study to Determine the Efficacy and Safety of Vedolizumab in Prevention of Endoscopic Recurrence of Crohn's Disease in Patients with Ileo-colonic Surgical Resection and Ileocolonic Anastamosis : REPREVIO (recurrence prevention with Entyvio)

The primary objective of this prospective placebo-controlled study is to assess the ability of vedolizumab to prevent postoperative endoscopic recurrence of Crohn*s disease in the neoterminal ileum.

A multi-center randomized controlled study of primary prevention of esophageal variceal bleeding in cirrhotic patients treated with HVPG-guided beta- blocker therapy or standard heart rate-guided beta-blocker therapy.

To determine cost-effectiveness of hepatic venous pressure gradient (HVPG)-guided nonselective beta-blocker therapy as compared to standard heart rate-guided beta-blocker therapy in the primary prevention of esophageal variceal bleeding in cirrhotic…

The effect of lactose consumption in lactase non-persistent individuals on gut microbiota

The primary objective of this study is to assess whether repetitive consumption of an increasing dose of dietary lactose in LNPers induces colonic microbial adaptation by a shift in microbiota composition and functional potential as measured with…

A randomized, double-blinded placebo controlled trial to evaluate the efficacy of a multivitamin and mineral supplement to prevent infections in patients with inflammatory bowel disease.

To evaluate the efficacy of an over the counter multivitamin and mineral supplement, compared with an identically in appearance placebo on the incidence of infections in patients with inflammatory bowel disease with a high risk for infection.

Endoscopic sphincterotomy before fully covered self-expandable metal stent placement for malignant extrahepatic biliary obstruction to prevent pancreatitis: a randomised controlled trial

To investigate the role of endoscopic sphincterotomy prior to biliary fully covered SEMS (FCSEMS) placement in the prevention of post-ERCP pancreatitis.

Standard versus Pre-emptive Antibiotic Treatment to Reduce the Rate of Infectious Outcomes after Whipple procedure (SPARROW): a multicenter, randomized controlled trial

This study has been transitioned to CTIS with ID 2024-510766-16-00 check the CTIS register for the current data. This trial evaluates the additional value of pre-emptive antibiotic treatment on clinically relevant OSIs in patients undergoing…

PREventing Surgical Site occurrences using negative pressURE wound therapy

Primary Objective: Primary objective of this trial will be to determine whether iNPWT reduces the number of patients with clinically relevant* SSOs after (potentially) contaminated ventral hernia repair <30 days after surgery. *A SSO is…

Feasibility of Pre-emptive VACStent Placement after Ivor Lewis Esophagectomy, to Prevent Anastomotic Leakage (PREVENT feasibility study)

We aim to evaluate the technical and logistic feasibility and safety of pre-emptive VACStent placement in patients undergoing esophagectomy with gastric conduit reconstruction, to prevent anastomotic leakage by early endoscopic vacuum therapy (EVT…

DIGEST II

The primary objective of this study is to compare the effectiveness of two app-based interventions on diet quality and perceived stress compared to standard care.