114 results
The aims of this study are: 1) To prospectively determine the incidence of HPS/polyps and CRC in first-degree relatives of patients with HPS so as to define whether screening of this group is justified.2) To assess the proportion of individuals that…
1) Identify chemopreventive properties of mesalazine in patients at high risk of recurrent (nonfamilial) colorectal adenomas by evaluating the effect of treatment on apoptosis and proliferation in histologically normal sigmoid and rectal mucosa…
Disease activity, perianal involvement and lesion localisation are important influential parameters making sure no pregnancy is exactly alike and mode of delivery needs to be considered on an individual patient level.A complete anorectal function…
To investigate the feasibility of using L-PRP on anastomosis to prevent septic complications from occuring.
Implementation of a biobank infrastructure to facilitate development and improvement of screening markers for colorectal neoplasia. New biomarkers will be compared to state of the art tests, e.g. currently FIT.
To assess whether a biological mesh (collagen tissue matrix) reduces the incidence of clinically detectable stoma closure site hernias at two years compared to standard closure techniques.
Our primary objective is to study the effect of perioperative intravenous supplementation of omega-3 fatty acids on the perioperative inflammatory response compared to a saline control in patients undergoing surgery for colon cancer.
The aim of this project is to study the effect of nicotine gum chewing in the prevention or reduction of POI and reduction of opioid use on patients who underwent elective colorectal surgery, and evaluate its safety and possible adverse effects.
To assess in a cohort of patients with established FAP:1 The efficacy of MPA in terms of reduction of number of colonic polyps, by means of Endoscopic Appearance of Polyposis (EAP) index.2 The effect on histological parameters and biological…
Investigate the effect of acidic and neutral oligosaccharides supplemented enteral nutrition on infectious morbidity, feeding tolerance and short-term outcome in VLBW infants. Furthermore, an attempt is made to elucidate the role of acidic and…
1) Study the chemopreventive potential of 5-ASA and UDCA in UC by evaluating the effect of treatment with these agents on ACF number, size and rate of dysplasia. 2) Gain mechanistic insight into the chemopreventive properties of 5-ASA and UDCA by…
The effectivity of a standard preventing constipation and treatment list, designed by the hospital nutritionteam, will show that neurological patients during their stay in the hospital develop less constipation.
1. Development of a prevention strategy for CD in children from high risk families for the disease by induction of oral tolerance to gluten;2. Identification of the immunological mechanisms involved in initiating the aberrant response to gluten…
The primary objective is to compare the efficacy of palifermin relative to placebo when given either pre-and post-high dose chemotherapy or pre-high dose chemotherapy only with regard to the severity of oral mucositis.
Study the risk of colorectal adenomas in patients detected with duodenal adenomas.
The primary objective of this clinical survey is to investigate the difference in morbidity and mortality after elective abdominal surgery for colon or rectal carcinoma in different age groups (55-75 years and older than 75 years).and to determine…
At first, to describe the UC, CD, and IBS outpatient population in the Netherlands. Secondly to gain insight into disease and treatment characteristics, as well as lifestyle and clinical factors identified as potential risk factors of a UC, CD, and…
The effects of the synbiotic Ecologic 825/scFOS on intestinal barrier function and immune modulation
The primary objective of this study is to assess the effects of the symbiotic Ecologic 825/scFOS on intestinal epithelial permeability.This study has five secondary objectives:1. The first secondary objective of this study is to study the microbiota…
We would like to conduct a multicentre randomised controlled clinical trial to compare the difference in early postoperative pain after unilateral primary inguinal hernia repair in males. The procedures will be performed in day surgery. Early…
We want to study whether consumption of Protecflor can improve the resistance of humans to intestinal ETEC infection. An important parameter of intestinal resistance is the so-called colonization resistance. The colonization resistance is inversely…